Close relationships, inflammation, and health.
Close relationships, inflammation, and health.
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DOI：
10.1016/j.neubiorev.2009.09.003
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发表时间：
2010-09
影响因子：
8.2
通讯作者：
Hantsoo, Liisa
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser, Janice K.;Gouin, Jean-Philippe;Hantsoo, Liisa
关键词：
Kiecolt-glaser, j.k.。Gouin和L. Hantsoo，亲密关系，炎症和健康。中国生物医学工程学报，2009,32(5):557 - 557。人际关系的不同方面，包括社会整合、社会支持和社会冲突，都与炎症有关。本文总结了与基因表达、细胞内信号传导机制和炎症生物标志物相关的质量和数量的证据，并强调了密切关系影响炎症反应的生物学和心理学途径。关系冲突和较低的社会支持可以直接（通过中枢神经系统/神经/内分泌/免疫生物行为途径）或间接（通过促进抑郁、情绪应激反应和有害健康行为）有效调节促炎细胞因子的分泌。因此，对健康行为的全面评估和对关键方法问题的关注对于确定炎症关系的贡献是必要的，因此我们强调了在研究设计中要考虑的程序问题。尽管在方法上存在一些显著的挑战，但有证据表明，更多地了解亲密关系如何影响炎症，将为人际关系影响健康的方式提供重要的新见解。
KIECOLT-GLASER, J.K., J-P. Gouin, and L. Hantsoo, Close Relationships, Inflammation, and Health. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2009.- Different aspects of personal relationships including social integration, social support, and social conflict have been related to inflammation. This article summarizes evidence linking the quality and quantity of relationships with gene expression, intracellular signaling mechanisms, and inflammatory biomarkers, and highlights the biological and psychological pathways through which close relationships impact inflammatory responses. Relationship conflict and lower social support can effectively modulate proinflammatory cytokine secretion both directly (via CNS/neural/endocrine/immune biobehavioral pathways), and indirectly, by promoting depression, emotional stress responses, and detrimental health behaviors. Accordingly, thorough assessments of health behaviors and attention to key methodological issues are necessary to identify the contributions of relationships to inflammation, and thus we highlight procedural issues to be considered in the design of studies. Despite some notable methodological challenges, the evidence suggests that learning more about how close relationships influence inflammation will provide important new insights into the ways that relationships impact health.
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DOI：
10.1073/pnas.1531903100
发表时间：
2003-07-22
影响因子：
11.1
作者：
Kiecolt-Glaser, JK;Preacher, KJ;Glaser, R
通讯作者：
Glaser, R
影响因子：
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作者：
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通讯作者：
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影响因子：
15.1
作者：
Cole, Steve W.
通讯作者：
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影响因子：
10.6
作者：
Harrison NA;Brydon L;Walker C;Gray MA;Steptoe A;Critchley HD
通讯作者：
Critchley HD
影响因子：
6.3
作者：
Eng, PM;Kawachi, I;Rimm, EB
通讯作者：
Rimm, EB