Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia.
Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia.
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DOI：
10.1016/j.pneurobio.2009.10.008
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发表时间：
2010-02-09
影响因子：
6.7
通讯作者：
Goldowitz D
中科院分区：
文献类型：
--
作者：
Freedman R;Goldowitz D
海马结构在认知功能中起着至关重要的作用。塑造海马结构的发育事件正在不断被阐明，它们对大脑功能的影响正在出现，并将这些进展应用于对治疗脑功能障碍具有重要可能性的干预措施。本章讲述的故事是关于使用眼内移植方法来阐明齿状回和邻近海马体发育的内在和外在特征，以及一个分子在海马体和精神分裂症中的作用。精神分裂症最初被概念为多巴胺能神经传递功能障碍，现在已知涉及多个神经元系统。海马神经元功能障碍正在成为其标志性病理特征之一。对海马中间神经元发育和功能的基本了解构成了针对这种疾病的新治疗方案的基础。 α7-烟碱乙酰胆碱受体在啮齿动物这些神经元的发育和功能中的作用的证据导致了烟碱激动剂治疗精神分裂症认知功能障碍的人体试验，以及通过围产期补充胆碱来改善有精神分裂症风险的儿童海马发育的可能性，胆碱可以充当α7-烟碱 乙酰胆碱受体激动剂。
The hippocampal formation plays a critical role in cognitive function. The developmental events that shape the hippocampal formation are continuing to be elucidated and their implications for brain function are emerging as well as applying those advances to interventions that have important possibilities for the treatment of brain dysfunction. The story told in this chapter is about the use of the in oculo transplant method to illuminate intrinsic and extrinsic features that underlie the development of the dentate gyrus and adjacent hippocampus and the role of one molecule in the hippocampus and schizophrenia. Schizophrenia, originally conceptualized as a dysfunction in dopaminergic neurotransmission, is now known to involve multiple neuronal systems. Dysfunction of hippocampal neurons is emerging as one of its signature pathological features. Basic insights into the development and function of hippocampal interneurons form the basis of a new treatment initiative for this illness. Evidence for the role of the alpha 7-nicotinic acetylcholine receptor in the development and function of these neurons in rodents has led to human trials of nicotinic agonists for cognitive dysfunction in schizophrenia and the possibility of improving hippocampal development in children at risk for schizophrenia by perinatal supplementation with choline, which can act as an alpha 7-nicotinic acetylcholine receptor agonist.
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影响因子：
56.9
作者：
AYERLELIEVRE, C;OLSON, L;PERSSON, H
通讯作者：
PERSSON, H
影响因子：
3.8
作者：
FREEDMAN, R;ADLER, LE;WALDO, M
通讯作者：
WALDO, M
DOI：
10.1016/s0165-3806(03)00106-8
发表时间：
2003-07-12
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Adams, CE
通讯作者：
Adams, CE
影响因子：
2.9
作者：
Adams, CE;Freedman, R
通讯作者：
Freedman, R
影响因子：
2.9
作者：
Adams, CE;Stitzel, JA;Freedman, R
通讯作者：
Freedman, R