Meeting report: measuring endocrine-sensitive endpoints within the first years of life.
Meeting report: measuring endocrine-sensitive endpoints within the first years of life.
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DOI：
10.1289/ehp.11226
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发表时间：
2008-07
影响因子：
10.4
通讯作者：
Mieusset, Roger
中科院分区：
文献类型：
--
作者：
Arbuckle, Tye E.;Hauser, Russ;Swan, Shanna H.;Mao, Catherine S.;Longnecker, Matthew P.;Main, Katharina M.;Whyatt, Robin M.;Mendola, Pauline;Legrand, Melissa;Rovet, Joanne;Till, Christine;Wade, Mike;Jarrell, John;Matthews, Stephen;Van Vliet, Guy;Bornehag, Carl-Gustaf;Mieusset, Roger
关键词：
2007年4月30日至5月1日，在加拿大安大略的渥太华举办了题为“生命最初几年内分泌相关终点评估”的国际讲习班。来自北美和欧洲的一些妊娠队列研究的代表介绍了测量生命早期各种内分泌敏感终点的备选方案，并讨论了与执行和使用这些措施有关的问题。讲习班的重点是测量生殖道发育终点[例如，肛门生殖器距离（AGD）]，内分泌状态和婴儿人体测量。研讨会与会者尽可能努力制定或建议标准化的衡量标准，以便比较和汇集各项研究的数据。推荐的结果包括大腿脂肪褶皱、乳房大小、阴道细胞学、AGD、睾丸位置、睾丸大小和阴茎生长，大部分讨论集中在生殖器检查上。尽管生殖器检查期间推荐的许多结果指标与暴露于干扰内分泌的化学物质有关，人们对这些影响如何预测以后的生殖健康或其他慢性健康状况知之甚少。
An international workshop titled “Assessing Endocrine-Related Endpoints within the First Years of Life” was held 30 April–1 May 2007, in Ottawa, Ontario, Canada. Representatives from a number of pregnancy cohort studies in North America and Europe presented options for measuring various endocrine-sensitive endpoints in early life and discussed issues related to performing and using those measures. The workshop focused on measuring reproductive tract developmental endpoints [e.g., anogenital distance (AGD)], endocrine status, and infant anthropometry. To the extent possible, workshop participants strove to develop or recommend standardized measurements that would allow comparisons and pooling of data across studies. The recommended outcomes include thigh fat fold, breast size, vaginal cytology, AGD, location of the testis, testicular size, and growth of the penis, with most of the discussion focusing on the genital exam. Although a number of outcome measures recommended during the genital exam have been associated with exposure to endocrine-disrupting chemicals, little is known about how predictive these effects are of later reproductive health or other chronic health conditions.
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影响因子：
5.1
作者：
CALLEGARI, C;EVERETT, S;BRASEL, JA
通讯作者：
BRASEL, JA
影响因子：
5.8
作者：
Chellakooty, M;Schmidt, IM;Main, KM
通讯作者：
Main, KM
影响因子：
2.3
作者：
Troisi, R;Potischman, N;Hoover, RN
通讯作者：
Hoover, RN
影响因子：
3.6
作者：
Schmidt, IM;Chellakooty, M;Main, KM
通讯作者：
Main, KM
影响因子：
5.2
作者：
SCORER, CG
通讯作者：
SCORER, CG