Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age.
Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age.
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DOI：
10.1155/2018/2380596
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发表时间：
2018
影响因子：
2
通讯作者：
Brand RE
中科院分区：
文献类型：
--
作者：
Chao DT;Shah NH;Zeh HJ 3rd;Singhi AD;Bahary N;McGrath KM;Fasanella KE;Zureikat AH;Whitcomb DC;Brand RE
Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset. Retrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI. Complete BMI and baseline covariate data was available in 319 PC patients. Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7). No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; p = 0.65). An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.
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影响因子：
24.5
作者：
Kantor ED;Udumyan R;Signorello LB;Giovannucci EL;Montgomery S;Fall K
通讯作者：
Fall K
影响因子：
9.8
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Anderson, Michelle A.;Zolotarevsky, Eugene;Cooper, Kristine L.;Sherman, Simon;Shats, Oleg;Whitcomb, David C.;Lynch, Henry T.;Ghiorzo, Paola;Rubinstein, Wendy S.;Vogel, Kristen J.;Sasson, Aaron R.;Grizzle, William E.;Ketcham, Marsha A.;Lee, Shih-Yuan;Normolle, Daniel;Plonka, Caitlyn M.;Mertens, Amy N.;Tripon, Renee C.;Brand, Randall E.
通讯作者：
Brand, Randall E.
影响因子：
7.1
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Biro, Frank M.;Wien, Michelle
通讯作者：
Wien, Michelle
影响因子：
3.8
作者：
Levi, Zohar;Kark, Jeremy D.;Shamiss, Ari
通讯作者：
Shamiss, Ari
影响因子：
5.9
作者：
Lowenfels, AB;Maisonneuve, P;Whitcomb, DC
通讯作者：
Whitcomb, DC