The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank.
The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank.
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DOI：
10.1038/s41416-020-01210-y
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发表时间：
2021-04
影响因子：
8.8
通讯作者：
Rohan TE
中科院分区：
文献类型：
--
作者：
Arthur RS;Dannenberg AJ;Kim M;Rohan TE
正常体重个体（体重指数（BMI）18.5-24.9 kg/m2）的体脂组成与癌症风险之间的关联尚不清楚。我们在2006年至2010年期间入选英国生物银行队列的149，928名正常体重个体（40-70岁）中检查了肥胖测量与乳腺癌（绝经后），子宫内膜癌，卵巢癌和结肠/直肠癌发病风险的相关性。所有的体脂指标均与浸润性绝经后乳腺癌风险呈正相关（最高五分位数（Q5）与最低五分位数（Q1）的风险比（HR）范围为腰围（WC）1.32（95% CI：1.09-1.60）至BMI 1.56（1.28-1.90））。躯干脂肪质量指数（HRQ 5 vs Q1：1.72，95%CI：1.02-2.89）和WC（HRQ 5 vs Q1：1.65，95%CI：1.01-2.70）与子宫内膜癌风险呈正相关。在男性中，躯干脂肪：躯干脂肪游离质量比、躯干脂肪：腿部脂肪质量比和（HRQ 5 vs Q1：1.63，95%CI：1.02-2.60; 1.92，1.20-3.07和1.68，1.05-2.66）与结肠癌风险呈正相关。没有一项体脂测量与女性患卵巢癌或结直肠癌的风险相关。这项研究的结果表明，目前基于BMI的正常体重类别包括患某些肥胖相关癌症风险增加的个体。
The association between body fat composition and risk of cancer in normal weight individuals (body mass index (BMI) 18.5–24.9 kg/m2) is unclear. We examined the association of measures of adiposity with risk of incident cancers of the breast (postmenopausal), endometrium, ovary and colon/rectum among 149,928 normal weight individuals (40–70 years) who were enrolled in the UK Biobank cohort between 2006 and 2010. All of the body fat measures were positively associated with invasive postmenopausal breast cancer risk (hazard ratios (HR) for the uppermost quintile (Q5) versus the lowest quintile (Q1) ranged from 1.32 (95% CI: 1.09–1.60) for waist circumference (WC) to 1.56 (1.28–1.90) for BMI). Trunk fat mass index (HRQ5 vs Q1: 1.72, 95% CI: 1.02–2.89) and WC (HRQ5 vs Q1: 1.65, 95% CI: 1.01–2.70)) were positively associated with risk of endometrial cancer. Among males, trunk fat:trunk fat free mass ratio, trunk fat:leg fat mass ratio and (HRQ5 vs Q1: 1.63, 95% CI: 1.02–2.60; 1.92, 1.20–3.07 and 1.68, 1.05–2.66, respectively) were positively associated with colon cancer risk. None of the body fat measures was associated with risk of ovarian cancer or colorectal cancer in women. The findings of this study suggest that the current normal weight category based on BMI includes individuals who are at increased risk of some obesity-related cancers.
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影响因子：
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作者：
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