Photobiomodulation prevents PTSD-like memory impairments in rats.
Photobiomodulation prevents PTSD-like memory impairments in rats.
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DOI：
10.1038/s41380-021-01088-z
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发表时间：
2021-11
影响因子：
11
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Li Y;Dong Y;Yang L;Tucker L;Zong X;Brann D;Hamblin MR;Vazdarjanova A;Zhang Q
对创伤事件进行编码的精确恐惧记忆使个人能够避开危险并识别安全。然而，恐惧记忆受损(情境健忘症)会使个人面临患上创伤后应激障碍(PTSD)的风险，这是因为在以后的生活中遇到与创伤相关的线索时，无法识别安全的背景。尽管情境遗忘是创伤后应激障碍的重要病因，但目前尚无可用于逆转情境遗忘的治疗方法，而且这种治疗方法是否能阻止创伤后应激障碍的发展尚不清楚。在这里，我们报告(I)单剂量的经颅光生物调节(PBM)在音调恐惧条件作用后立即应用可以逆转情境遗忘。在重温“危险”情境的大鼠中，PBM处理保留了适当高水平的情境恐惧记忆，而对照组大鼠则表现出记忆障碍。(Ii)在记忆回忆后应用单剂量的PBM可以减少背景记忆和线索记忆测试中的背景恐惧。(Iii)在复杂的PTSD反复创伤模型中，早期给予PBM干预的大鼠在线索记忆测试中有效地区分了安全和危险，重要的是，这些大鼠没有出现类似PTSD的症状和共病。(Iv)最后，我们报告了在记忆巩固的早期干预窗口中应用PBM可以促进恐惧消退。我们的结果表明，在创伤事件或其记忆回忆后立即应用PBM治疗可以保护大鼠的情境恐惧记忆，防止大鼠出现类似创伤后应激障碍的精神病理恐惧。
A precise fear memory encoding a traumatic event enables an individual to avoid danger and identify safety. An impaired fear memory (contextual amnesia), however, puts the individual at risk of developing posttraumatic stress disorder (PTSD) due to the inability to identify a safe context when encountering trauma-associated cues later in life. Although it is gaining attention that contextual amnesia is a critical etiologic factor for PTSD, there is no treatment currently available that can reverse contextual amnesia, and whether such treatment can prevent the development of PTSD is unknown. Here, we report that (I) a single dose of transcranial photobiomodulation (PBM) applied immediately after tone fear conditioning can reverse contextual amnesia. PBM treatment preserved an appropriately high level of contextual fear memory in rats revisiting the “dangerous” context, while control rats displayed memory impairment. (II) A single dose of PBM applied after memory recall can reduce contextual fear during both contextual and cued memory testing. (III) In a model of complex PTSD with repeated trauma, rats given early PBM interventions efficiently discriminated safety from danger during cued memory testing and, importantly, these rats did not develop PTSD-like symptoms and comorbidities. (IV) Finally, we report that fear extinction was facilitated when PBM was applied in the early intervention window of memory consolidation. Our results demonstrate that PBM treatment applied immediately after a traumatic event or its memory recall can protect contextual fear memory and prevent the development of PTSD-like psychopathological fear in rats.
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DOI：
10.1016/j.bbacli.2016.09.002
发表时间：
2016-12
期刊：
BBA clinical
影响因子：
--
作者：
Hamblin, Michael R
通讯作者：
Hamblin, Michael R
低水平激光（光）治疗增加了C2C12肌管中的线粒体膜电位和ATP合成，在3-6 h时峰值响应。
影响因子：
3.3
作者：
Ferraresi C;Kaippert B;Avci P;Huang YY;de Sousa MV;Bagnato VS;Parizotto NA;Hamblin MR
通讯作者：
Hamblin MR
影响因子：
2.7
作者：
Jadidi, Majid;Firoozabadi, Seyed Mohammad;Taherian, Abbas Ali
通讯作者：
Taherian, Abbas Ali
影响因子：
56.9
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
7.7
作者：
Gruene, Tina M.;Flick, Katelyn;Shansky, Rebecca M.
通讯作者：
Shansky, Rebecca M.