Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study.
Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study.
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DOI：
10.3389/fimmu.2022.858875
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
免疫功能改变以及脂肪酸摄入和状态与1型糖尿病的发展有关。我们的目的是研究1型糖尿病遗传风险增加的幼儿中脂肪酸和免疫学标志物之间的关系，以确定与胰岛自身免疫发展相关的假定机制。在降低遗传风险（TRIGR）辅助研究（Divia）中，从15个国家2002年至2007年出生的儿童中获得了用于脂肪酸和免疫标志物测量的血清样本。病例儿童（n = 95）被定义为至少有两个重复阳性的四个糖尿病相关的自身抗体。对于每个病例儿童，选择与国家和出生日期匹配的对照儿童（n = 173）。在6月龄和12月龄时测定脐带血中的血清脂肪酸和免疫学指标。计算脂肪酸和免疫学标志物之间的斯皮尔曼相关系数。循环脂肪酸和免疫学标志物之间的相关性是不同的情况下，儿童谁开发胰岛自身免疫比对照组儿童已经在出生时继续在第一年的生活。在病例儿童中，饱和脂肪酸（SFA）与免疫学标志物显示出更强的相关性，而在对照组中，多不饱和脂肪酸（PUFA）显示出更强的相关性。在病例中，SFA与先前与1型糖尿病疾病过程相关的几种免疫学标志物（CXCL 10、IL-6、IL-9、IL-17和CM-CSF）相关。研究结果表明，脂肪酸可能在疾病发展的早期阶段具有免疫调节潜力，尽管脂肪酸和免疫途径之间的因果关系仍有待探讨。NCT00179777
Altered immune functions as well as fatty acid intake and status have been associated with the development of type 1 diabetes. We aimed to study the relationship between fatty acids and immunological markers in young children with increased genetic risk for type 1 diabetes in order to define putative mechanisms related to development of islet autoimmunity. Serum samples for fatty acid and immunological marker measurements were obtained in the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) ancillary study (Divia) from children born between 2002 and 2007 in 15 countries. Case children (n = 95) were defined as having repeated positivity for at least two out of four diabetes-associated autoantibodies. For each case child, control children were selected matched for country and date of birth (n = 173). Serum fatty acids and immunological markers were measured from cord serum and at the age of 6 and 12 months. Spearman correlation coefficients were calculated between fatty acids and immunological markers. Correlations between circulating fatty acids and immunological markers were different in case children who developed islet autoimmunity than in control children already at birth continuing across the first year of life. In case children, saturated fatty acids (SFAs) showed stronger correlations with immunological markers, while in controls, polyunsaturated fatty acids (PUFAs) showed stronger correlations. In cases, SFAs were associated with several immunological markers (CXCL10, IL-6, IL-9, IL-17, and CM-CSF) previously linked to the type 1 diabetes disease process. Findings indicate that fatty acids could have immunomodulatory potential in the early phase of the disease development, although causality between fatty acids and the immunological pathways remains to be explored. NCT00179777
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影响因子：
3.7
作者：
Li K;Huang T;Zheng J;Wu K;Li D
通讯作者：
Li D
影响因子：
5.9
作者：
Lankinen M;Uusitupa M;Schwab U
通讯作者：
Schwab U
影响因子：
120.7
作者：
Knip, Mikael;Akerblom, Hans K.;Wasikowa, Renata
通讯作者：
Wasikowa, Renata
DOI：
10.1111/j.1600-0897.2011.01057.x
发表时间：
2011-12-01
影响因子：
3.6
作者：
Lindehammer, Sabina Resic;Fex, Malin;Lernmark, Ake
通讯作者：
Lernmark, Ake
影响因子：
3.4
作者：
Chase HP;Boulware D;Rodriguez H;Donaldson D;Chritton S;Rafkin-Mervis L;Krischer J;Skyler JS;Clare-Salzler M;Type 1 Diabetes TrialNet Nutritional Intervention to Prevent (NIP) Type 1 Diabetes Study Group
通讯作者：
Type 1 Diabetes TrialNet Nutritional Intervention to Prevent (NIP) Type 1 Diabetes Study Group