Resting-state hippocampal connectivity correlates with symptom severity in post-traumatic stress disorder.
Resting-state hippocampal connectivity correlates with symptom severity in post-traumatic stress disorder.
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DOI：
10.1016/j.nicl.2014.07.017
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Taylor MJ
中科院分区：
文献类型：
--
作者：
Dunkley BT;Doesburg SM;Sedge PA;Grodecki RJ;Shek PN;Pang EW;Taylor MJ
创伤后应激障碍（PTSD）是一种严重的精神健康损伤，可以在经历创伤性生活事件后表现出来。这种疾病的特征是症状的重新体验，回避，情感麻木和过度觉醒。虽然其病因学和由此产生的病理学被更好地理解，但对潜在的皮质病理生理学知之甚少，特别是功能连接的变化是否可能与该疾病有关。在这里，我们使用非侵入性神经成像与脑磁图检查功能连接在一个休息状态协议在战斗相关的创伤后应激障碍组（n = 23），和军事对照组（n = 21）。我们确定了非典型的远程超连接在高伽玛波段的休息状态网络中的战斗相关的创伤后应激障碍的人口相比，士兵经历了可比的环境暴露，但没有发展创伤后应激障碍。使用图形分析，我们证明了相关大脑区域的明显网络连接与认知行为结果相关。我们还发现，PTSD组的左海马连接与完善的PTSD检查表（PCL）评分相关。这些发现表明，非典型的同步神经相互作用可能是PTSD心理症状的基础，同时也具有作为潜在生物标志物的实用性，以帮助诊断和监测该疾病。患有PTSD的士兵在高伽马静息状态下显示出更高的连通性。PTSD患者的左额叶、颞叶和海马区表现为超连通性。在没有PTSD的士兵中，明显的刺激诱导了连接性的增加。左海马连接强度与PTSD症状严重程度相关。
Post-traumatic stress disorder (PTSD) is a serious mental health injury which can manifest after experiencing a traumatic life event. The disorder is characterized by symptoms of re-experiencing, avoidance, emotional numbing and hyper-arousal. Whilst its aetiology and resultant symptomology are better understood, relatively little is known about the underlying cortical pathophysiology, and in particular whether changes in functional connectivity may be linked to the disorder. Here, we used non-invasive neuroimaging with magnetoencephalography to examine functional connectivity in a resting-state protocol in the combat-related PTSD group (n = 23), and a military control group (n = 21). We identify atypical long-range hyperconnectivity in the high-gamma-band resting-state networks in a combat-related PTSD population compared to soldiers who underwent comparable environmental exposure but did not develop PTSD. Using graph analysis, we demonstrate that apparent network connectivity of relevant brain regions is associated with cognitive-behavioural outcomes. We also show that left hippocampal connectivity in the PTSD group correlates with scores on the well-established PTSD Checklist (PCL). These findings indicate that atypical synchronous neural interactions may underlie the psychological symptoms of PTSD, whilst also having utility as a potential biomarker to aid in the diagnosis and monitoring of the disorder. Soldiers with PTSD display increased connectivity in high gamma resting state. Left frontal, temporal and hippocampus regions show hyperconnectivity in PTSD. Emotionally-salient stimuli induced increased connectivity in soldiers without PTSD. Connectivity strength in left hippocampus correlates with PTSD symptom severity.
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DOI：
10.1038/nrn3339
发表时间：
2012-11
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Pitman RK;Rasmusson AM;Koenen KC;Shin LM;Orr SP;Gilbertson MW;Milad MR;Liberzon I
通讯作者：
Liberzon I
影响因子：
9.2
作者：
Nir, Yuval;Fisch, Lior;Malach, Rafael
通讯作者：
Malach, Rafael
影响因子：
4
作者：
Engdahl, B.;Leuthold, A. C.;Georgopoulos, A. P.
通讯作者：
Georgopoulos, A. P.
影响因子：
4
作者：
Georgopoulos, A. P.;Tan, H-R M.;Engdahl, B.
通讯作者：
Engdahl, B.
DOI：
10.1177/070674371205701205
发表时间：
2012-12-01
影响因子：
4
作者：
Garber, Bryan G.;Zamorski, Mark A.;Jetly, Col Rakesh
通讯作者：
Jetly, Col Rakesh