Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye.
Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye.
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胎儿眼睛中透明，脉络膜和视网膜血管的发育。
DOI：
10.1016/j.preteyeres.2017.10.001
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发表时间：
2018-01
影响因子：
17.8
通讯作者：
McLeod DS
中科院分区：
文献类型：
--
作者：
Lutty GA;McLeod DS
眼部血管的发育是完全同步的，以提供形成人眼所需的营养和氧气。胎儿玻璃体血管，包括玻璃体血管、固有玻璃体血管和小体血管膜，最初在妊娠4-6周左右通过血液血管发生（血液和血管从一个共同的祖细胞——血管母细胞发育而来）发育。这种短暂的胎儿血管在12wg左右通过血管生成（从原始血管萌发）而扩张，直到视网膜血管开始形成。然后，在巨噬细胞/透明细胞的帮助下，胎儿的血管系统通过凋亡而退化。人体脉络膜脉管系统也是通过类似的过程形成的，并将向外视网膜提供营养和氧气。小叶血管在致密的胶原组织中发育，与形成血管内皮生长因子（VEGF）的细胞（视网膜色素上皮）并列。这种上皮/内皮的关系对于维持整个生命中血管系统的功能和维持其开窗状态至关重要。小叶毛细血管系统（绒毛膜毛细血管）首先通过血液血管生成发育，然后中间脉络膜血管通过血管生成形成，从绒毛膜毛细血管出芽。人类视网膜血管系统是最后发育的。它通过血管发生、CXCR4+/CD39+成血管细胞或血管祖细胞的组装而发展，可能利用Muller细胞Notch1或轴突神经匹林-1来指导表达信号蛋白3a的成血管细胞。中央凹从未形成视网膜血管系统，这可能是由于视网膜的中央凹无血管区表达高水平的抗血管生成因子。从这些研究中，很明显，小鼠眼部血管的发育不能代表人类胎儿、脉络膜和视网膜血管的发育。
The development of the ocular vasculatures is perfectly synchronized to provide the nutritional and oxygen requirements of the forming human eye. The fetal vasculature of vitreous, which includes the hyaloid vasculature, vasa hyaloidea propria, and tunica vasculosa lentis, initially develops around 4–6 weeks gestation (WG) by hemo-vasculogenesis (development of blood and blood vessels from a common progenitor, the hemangioblast). This transient fetal vasculature expands around 12 WG by angiogenesis (budding from primordial vessels) and remains until a retinal vasculature begins to form. The fetal vasculature then regresses by apoptosis with the assistance of macrophages/hyalocytes. The human choroidal vasculature also forms by a similar process and will supply nutrients and oxygen to outer retina. This lobular vasculature develops in a dense collagenous tissue juxtaposed with a cell constitutively producing vascular endothelial growth factor (VEGF), the retinal pigment epithelium. This epithelial/endothelial relationship is critical in maintaining the function of this vasculature throughout life and maintaining it’s fenestrated state. The lobular capillary system (choriocapillaris) develops first by hemo-vasculogenesis and then the intermediate choroidal blood vessels form by angiogenesis, budding from the choriocapillaris. The human retinal vasculature is the last to develop. It develops by vasculogenesis, assembly of CXCR4+/CD39+ angioblasts or vascular progenitors perhaps using Muller cell Notch1 or axonal neuropilinin-1 for guidance of semaphorin 3A-expressing angioblasts. The fovea never develops a retinal vasculature, which is probably due to the foveal avascular zone area of retina expressing high levels of anti-angiogenic factors. From these studies, it is apparent that development of the mouse ocular vasculatures is not representative of the development of the human fetal, choroidal and retinal vasculatures.
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影响因子：
20.3
作者：
Drake, CJ;Fleming, PA
通讯作者：
Fleming, PA
影响因子：
64.5
作者：
LANG, RA;BISHOP, JM
通讯作者：
BISHOP, JM
基质细胞衍生的 Factor-1/CXCR4 信号传导在体外改变人胚胎干细胞衍生的内皮细胞的毛细血管样组织
影响因子：
5.2
作者：
Chen, Tong;Bai, Hao;Wang, Zack Z.
通讯作者：
Wang, Zack Z.
影响因子：
4.4
作者：
Chan-Ling, T;McLeod, DS;Lutty, GA
通讯作者：
Lutty, GA
DOI：
10.1007/bf00413534
发表时间：
1980-01-01
期刊：
ALBRECHT VON GRAEFES ARCHIV FUR KLINISCHE UND EXPERIMENTELLE OPHTHALMOLOGIE
影响因子：
--
作者：
BALAZS, EA;TOTH, LZ;OZANICS, V
通讯作者：
OZANICS, V