Glutathione peroxidases as oncotargets.
Glutathione peroxidases as oncotargets.
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DOI：
10.18632/oncotarget.20278
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发表时间：
2017-10-03
期刊：
影响因子：
--
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Jiao Y;Wang Y;Guo S;Wang G
氧化应激是自由基、活性氧和内源性抗氧化防御机制之间平衡的紊乱。氧化应激是活性氧的产生与生物系统对活性中间体解毒或修复所产生的损伤的能力之间不平衡的结果。越来越多的证据表明氧化应激参与了各种生理和病理过程，包括DNA损伤、增殖、细胞粘附和癌细胞的存活。谷胱甘肽过氧化物酶（GPx）（EC 1.11.1.9）是具有过氧化物酶活性的酶家族，其主要生物学作用是通过减少脂质氢过氧化物以及游离过氧化氢来保护生物体免受氧化损伤。目前，已在人体中鉴定出GPx的8个亚成员，它们都能够减少H2O2和可溶性脂肪酸氢过氧化物。大量的出版物已经证明GPx在癌发生的不同阶段具有重要作用。本文就GPxs在肿瘤中的作用作一综述。更好地理解GPx的机制将有助于开发和改进癌症治疗模型。
Oxidative stress is a disturbance in the equilibrium among free radicals, reactive oxygen species, and endogenous antioxidant defense mechanisms. Oxidative stress is a result of imbalance between the production of reactive oxygen and the biological system’s ability to detoxify the reactive intermediates or to repair the resulting damage. Mounting evidence has implicated oxidative stress in various physiological and pathological processes, including DNA damage, proliferation, cell adhesion, and survival of cancer cells. Glutathione peroxidases (GPxs) (EC 1.11.1.9) are an enzyme family with peroxidase activity whose main biological roles are to protect organisms from oxidative damage by reducing lipid hydroperoxides as well as free hydrogen peroxide. Currently, 8 sub-members of GPxs have been identified in humans, all capable of reducing H2O2 and soluble fatty acid hydroperoxides. A large number of publications has demonstrated that GPxs have significant roles in different stages of carcinogenesis. In this review, we will update recent progress in the study of the roles of GPxs in cancer. Better mechanistic understanding of GPxs will potentially contribute to the development and advancement of improved cancer treatment models.
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影响因子：
5.6
作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1749-6632.2012.06574.x
发表时间：
2012-01-01
期刊：
ENVIRONMENTAL STRESSORS IN BIOLOGY AND MEDICINE
影响因子：
--
作者：
Brigelius-Flohe, Regina;Kipp, Anna Patricia
通讯作者：
Kipp, Anna Patricia