The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety.
The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety.
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DOI：
10.1016/j.pnpbp.2009.05.013
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发表时间：
2009-11-13
影响因子：
5.6
通讯作者：
Rainnie, Donald G.
中科院分区：
文献类型：
--
作者：
Hammack, Sayamwong E.;Guo, Ji-Dong;Hazra, Rimi;Dabrowska, Joanna;Myers, Karyn M.;Rainnie, Donald G.
大量证据表明，终纹床核（BNST）的活动介导了人类和非人类动物多种形式的焦虑样行为。这些数据使许多研究人员认为，该核内的异常处理可能是人类焦虑症的根源，而有效的焦虑治疗可能会恢复正常的 BNST 功能。目前，一些最有效的焦虑症治疗方法是调节血清素 (5-HT) 系统的药物，数十年的研究表明，5-HT 的激活可以调节焦虑样行为。尽管存在这些事实，但相对较少的研究探讨了 BNST 内的活动如何受 5-HT 调节。在这里，我们回顾了我们自己的研究，使用体外全细胞膜片钳电生理学方法对含有 BNST 的脑切片进行研究，以确定 BNST 神经元对外源 5-HT 应用的反应。我们的数据表明，BNST 神经元对 5-HT 的反应是复杂的，显示出抑制性和兴奋性成分，这些成分由 5-HT1A、5-HT2A、5-HT2C 和 5-HT7 受体介导。此外，我们已经表明，选择性激活对 5-HT 的抑制性反应可减少焦虑样行为，并且我们描述的数据表明，对 5-HT 的兴奋性反应的激活可能会引起焦虑。我们认为，在正常状态下，5-HT 的功能是在暴露于威胁性刺激时抑制 BNST 内的活动（以及随之而来的焦虑样行为）；然而，我们认为BNST 5-HT受体亚型功能平衡的变化可能会改变BNST神经元的反应，以利于兴奋并产生增加焦虑的病理状态。
Substantial evidence has suggested that the activity of the bed nucleus of the stria terminalis (BNST) mediates many forms of anxiety-like behavior in human and non-human animals. These data have led many investigators to suggest that abnormal processing within this nucleus may underlie anxiety disorders in humans, and effective anxiety treatments may restore normal BNST functioning. Currently some of the most effective treatments for anxiety disorders are drugs that modulate serotonin (5-HT) systems, and several decades of research have suggested that the activation of 5-HT can modulate anxiety-like behavior. Despite these facts, relatively few studies have examined how activity within the BNST is modulated by 5-HT. Here we review our own investigations using in vitro whole-cell patch-clamp electrophysiological methods on brain sections containing the BNST to determine the response of BNST neurons to exogenous 5-HT application. Our data suggest that the response of BNST neurons to 5-HT is complex, displaying both inhibitory and excitatory components, which are mediated by 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors. Moreover, we have shown that the selective activation of the inhibitory response to 5-HT reduces anxiety-like behavior, and we describe data suggesting that the activation of the excitatory response to 5-HT may be anxiogenic. We propose that in the normal state, the function of 5-HT is to dampen activity within the BNST (and consequent anxiety-like behavior) during exposure to threatening stimuli; however, we suggest that changes in the balance of the function of BNST 5-HT receptor subtypes could alter the response of BNST neurons to favor excitation and produce a pathological state of increase anxiety.
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DOI：
10.1017/s1461145701002632
发表时间：
2001-12-01
影响因子：
4.8
作者：
Bagdy, G;Graf, M;Kantor, S
通讯作者：
Kantor, S
DOI：
10.1098/rstb.1997.0149
发表时间：
1997-11-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Davis, M;Walker, DL;Lee, Y
通讯作者：
Lee, Y
影响因子：
7.6
作者：
Broocks, A;Meyer, T;Rüther, E
通讯作者：
Rüther, E
影响因子：
10.6
作者：
Burghardt, NS;Sullivan, GM;LeDoux, JE
通讯作者：
LeDoux, JE
影响因子：
3.3
作者：
Abrams, JK;Johnson, PL;Lowry, CA
通讯作者：
Lowry, CA