Reproductive factors and risk of primary brain tumors in women.
Reproductive factors and risk of primary brain tumors in women.
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DOI：
10.1007/s11060-014-1427-0
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发表时间：
2014-06
影响因子：
3.9
通讯作者：
Egan, Kathleen M.
中科院分区：
文献类型：
--
作者：
Anic, Gabriella M.;Madden, Melissa H.;Nabors, L. Burton;Olson, Jeffrey J.;LaRocca, Renato V.;Thompson, Zachary J.;Pamnani, Shitaldas J.;Forsyth, Peter A.;Thompson, Reid C.;Egan, Kathleen M.
性别特异性发病模式和肿瘤细胞上激素受体的存在表明，性激素可能在原发性脑肿瘤的发病机制中发挥作用。然而，关于激素风险因素与脑肿瘤风险关系的流行病学研究一直不一致。我们在美国东南部进行的一项病例对照研究中，研究了生殖因素在胶质瘤和脑膜瘤发病中的作用，该研究包括507例胶质瘤病例，247例脑膜瘤病例和695例社区对照。非条件logistic回归用于估计比值比（OR）和95%置信区间（CI），调整年龄、种族、美国居住州和教育。初潮年龄越大，患神经胶质瘤的风险越高（≥15岁vs ≤12岁：OR = 1.65; 95% CI：1.11，2.45），在绝经前观察到更强的相关性（OR = 2.22; 95% CI：1.12，4.39）高于绝经后妇女（OR = 1.55; 95% CI：0.93，2.58）。与对照组相比，脑膜瘤病例更可能经历自然绝经（OR = 1.52; 95%CI：1.04，2.21），而胶质瘤病例不太可能长期使用口服避孕药（OR = 0.47; 95%CI：0.33，0.68）。增加产次与两种肿瘤的风险均无关。目前的研究结果与激素在女性脑肿瘤发病中的有限作用一致。越来越多的证据表明，初潮年龄越晚，患神经胶质瘤的风险越大。
Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the pathogenesis of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of reproductive factors in the onset of glioma and meningioma among women enrolled in a case-control study conducted in the Southeastern US that included 507 glioma cases, 247 meningioma cases, and 695 community-based controls. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) adjusting for age, race, US state of residence, and education. An older age at menarche was associated with an increased risk of glioma (≥15 years versus ≤12 years: OR = 1.65; 95% CI: 1.11, 2.45), with a stronger association observed in pre-menopausal (OR = 2.22; 95% CI: 1.12, 4.39) than post-menopausal (OR = 1.55; 95% CI: 0.93, 2.58) women. When compared to controls, meningioma cases were more likely to have undergone natural menopause (OR = 1.52; 95% CI: 1.04, 2.21) whereas glioma cases were less likely to be long term users of oral contraceptives (OR = 0.47; 95% CI: 0.33, 0.68). Increasing parity was not related to the risk of either tumor. Current findings are consistent with a limited role for hormones in the onset of brain tumors in women. Results contribute to a growing body of evidence that a later age at menarche increases the risk of glioma.
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影响因子：
4.1
作者：
Claus, Elizabeth B.;Calvocoressi, Lisa;Wrensch, Margaret
通讯作者：
Wrensch, Margaret
影响因子：
4.1
作者：
Jhawar, BS;Fuchs, CS;Stampfer, MJ
通讯作者：
Stampfer, MJ
影响因子：
3.8
作者：
Custer, Brian;Longstreth, W. T., Jr.;Van Belle, Gerald
通讯作者：
Van Belle, Gerald
影响因子：
5.8
作者：
JUUL, A;BANG, P;SKAKKEBAEK, NE
通讯作者：
SKAKKEBAEK, NE
影响因子：
3.8
作者：
González-Agüero, G;Ondarza, R;Camacho-Arroyo, I
通讯作者：
Camacho-Arroyo, I