Using arterial spin labeling perfusion MRI to explore how midazolam produces anterograde amnesia.
Using arterial spin labeling perfusion MRI to explore how midazolam produces anterograde amnesia.
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使用动脉自旋标记灌注 MRI 探讨咪达唑仑如何产生顺行性遗忘症
DOI：
10.1016/j.neulet.2012.06.019
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发表时间：
2012-08-01
影响因子：
2.5
通讯作者：
Reder LM
中科院分区：
文献类型：
--
作者：
Liang P;Manelis A;Liu X;Aizenstein HJ;Gyulai F;Quinlan JJ;Reder LM
虽然我们以前的工作表明，咪达唑仑诱导的记忆障碍的结果，从抑制新的协会形成，鲜为人知的是，这些影响背后的GABA激动剂对大脑的影响的神经相关。我们使用动脉自旋标记灌注MRI来测量与咪达唑仑对学习任意单词对能力的影响相关的脑血流变化。采用双盲、受试者内交叉设计，受试者在被扫描的同时研究单词对，以备后续的线索回忆测试。在注射生理盐水或咪达唑仑之前和之后，研究了不同单词对的列表。正如预期的那样，使用咪达唑仑后，记忆力严重受损。咪唑安定给药前后MRI信号对比显示左侧背外侧前额叶皮质（DLPFC）、左侧扣带回和左侧后扣带回/楔前叶CBF降低。即使在控制注射的任何影响后也观察到这些影响。在左侧DLPFC中发现咪达唑仑诱导的神经活动变化与记忆表现之间存在很强的相关性。这些发现提供了一致的证据，表明该区域在新的关联的形成中起着关键作用，并且该区域的低功能与顺行性遗忘有关。
While our previous work suggests that the midazolam-induced memory impairment results from the inhibition of new association formation, little is known about the neural correlates underlying these effects beyond the effects of GABA agonists on the brain. We used arterial spin-labeling perfusion MRI to measure cerebral blood flow changes associated with the effects of midazolam on ability to learn arbitrary word-pairs. Using a double-blind, within-subject cross-over design, subjects studied word-pairs for a later cued-recall test while they were scanned. Lists of different word-pairs were studied both before and after an injection of either saline or midazolam. As expected, recall was severely impaired under midazolam. The contrast of MRI signal before and after midazolam administration revealed a decrease in CBF in the left dorsolateral prefrontal cortex (DLPFC), left cingulate gyrus and left posterior cingulate gyrus/precuneus. These effects were observed even after controlling for any effect of injection. A strong correlation between the midazolam-induced changes in neural activity and memory performance was found in the left DLPFC. These findings provide converging evidence that this region plays a critical role in the formation of new associations and that low functioning of this region is associated with anterograde amnesia.
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影响因子：
9.8
作者：
Bulach, R;Myles, PS;Russnak, M
通讯作者：
Russnak, M
DOI：
10.1073/pnas.012467899
发表时间：
2002-01-08
影响因子：
11.1
作者：
Sperling, R;Greve, D;Albert, M
通讯作者：
Albert, M
影响因子：
4.1
作者：
Wezenberg, E.;Sabbe, B. G. C.;Verkes, R. J.
通讯作者：
Verkes, R. J.
影响因子：
3.4
作者：
Merritt, P;Hirshman, E;Berrigan, M
通讯作者：
Berrigan, M
影响因子：
2.5
作者：
Wang, Ze;Aguirre, Geoffrey K.;Detre, John A.
通讯作者：
Detre, John A.