Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a Chinese case-control study and updated meta-analysis.
Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a Chinese case-control study and updated meta-analysis.
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ADIPOQ 和 ADIPOR1 变异与结直肠癌风险之间的关联：一项中国病例对照研究和更新的荟萃分析
DOI：
10.1186/s12881-014-0137-y
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发表时间：
2014-12-17
影响因子：
--
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Ou Y;Chen P;Zhou Z;Li C;Liu J;Tajima K;Guo J;Cao J;Wang H
流行病学研究表明，脂联素(ADIPOQ)及其受体AdipoR1(脂联素受体1)的变异与结直肠癌(CRC)的风险有关；然而，结果并不确定。这项研究的目的是评估ADIPOQ和AdipoR1基因变异与中国人群结直肠癌风险之间的关系，采用以医院为基础的病例对照研究，并对现有的流行病学研究进行荟萃分析。通过以医院为基础的341例病例和727例对照的病例对照研究，评价ADIPOQ常见变异(rs266729、rs822395、rs2241766和rs1501299)和AdipoR1(rs1342387和rs12733285)与结直肠癌易感性的关系。对已发表的流行病学研究进行荟萃分析，以调查变异与结直肠癌风险之间的关系。在人群研究中，我们发现，AdipoR1的rs1342387变异与结直肠癌风险降低相关[调整后的优势比(OR) = 为0.74，95%可信区间(95%CI) = 为0.57-0.97；CT/TT与CC相比]。在随机效应模型下，CT/TT携带者与CC纯合子相比，合并OR为0.79(95%CI = 为0.66~0.95)(Q = 8.06，DF = 4，P = 0.089；I2 = 50.4%)。病例对照研究没有发现ADIPOQ上的rs266729、rs822395、rs2241766和rs1501299变异或rs12733285变异与AdipoR1和CRC易感性之间的显著关联，这与荟萃分析研究的结果一致。这些数据提示，AdipoR1上的rs1342387变异可能是一种新的CRC易感因素。本文的在线版本(doi：10.1186/s12881-0140137-y)包含补充材料，授权用户可以使用。
Epidemiological studies have suggested that variants on adiponectin (ADIPOQ) and its receptor ADIPOR1 (adiponectin receptor 1) are associated with colorectal cancer (CRC) risk; however, the results were inconclusive. The aim of the study was to evaluate the associations between the variants on ADIPOQ and ADIPOR1 and the CRC risk with a hospital-based case-control study in the Chinese population along with meta-analysis of available epidemiological studies. With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated. Meta-analysis of the published epidemiological studies was performed to investigate the associations between the variants and CRC risk. For the population study, we found that variant rs1342387 of ADIPOR1 was associated with a reduced risk for CRC [adjusted odds ratio (OR) = 0.74, 95% confidential intervals (95% CI) = 0.57-0.97; CT/TT vs. CC]. The meta-analysis also suggested a significant association for rs1342387 and CRC risk; the pooled OR was 0.79 (95% CI = 0.66-0.95) for the CT/TT carriers compared to CC homozygotes under the random-effects model (Q = 8.06, df = 4, P = 0.089; I2 = 50.4%). The case-control study found no significant association for variants rs266729, rs822395, rs2241766, and rs1501299 on ADIPOQ or variant rs12733285 on ADIPOR1 and CRC susceptibility, which were consistent with results from the meta-analysis studies. These data suggested that variant rs1342387 on ADIPOR1 may be a novel CRC susceptibility factor. The online version of this article (doi:10.1186/s12881-014-0137-y) contains supplementary material, which is available to authorized users.
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