A Two-Magnet System to Push Therapeutic Nanoparticles.
A Two-Magnet System to Push Therapeutic Nanoparticles.
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DOI：
10.1063/1.3530064
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Rutel IB
中科院分区：
文献类型：
--
作者：
Shapiro B;Dormer K;Rutel IB
磁场可以用来引导对磁敏感的纳米粒子到达疾病部位：感染、血块或肿瘤。任何一块磁铁总是吸引（拉）铁质或准磁性粒子向它靠近。在动物和人类的临床试验中，外部磁铁已被用于将治疗药物拉入皮肤附近的肿瘤。将磁性材料植入患者体内（在某些情况下是可行的方法）已被设想为达到更深层次目标的一种手段。然而，有许多临床需求，从内耳治疗到耐抗生素皮肤感染和心律失常，都将受益于磁性“注射”或推入纳米药物的能力。我们开发，分析，并实验证明了一种新颖，简单，有效的安排，只有两个永磁体，可以磁力推动粒子。这种系统可以治疗内耳疾病；由于血脑屏障，静脉注射或口服治疗无法到达的疾病。
Magnetic fields can be used to direct magnetically susceptible nanoparticles to disease locations: to infections, blood clots, or tumors. Any single magnet always attracts (pulls) ferro- or para-magnetic particles towards it. External magnets have been used to pull therapeutics into tumors near the skin in animals and human clinical trials. Implanting magnetic materials into patients (a feasible approach in some cases) has been envisioned as a means of reaching deeper targets. Yet there are a number of clinical needs, ranging from treatments of the inner ear, to antibiotic-resistant skin infections and cardiac arrhythmias, which would benefit from an ability to magnetically “inject”, or push in, nanomedicines. We develop, analyze, and experimentally demonstrate a novel, simple, and effective arrangement of just two permanent magnets that can magnetically push particles. Such a system might treat diseases of the inner ear; diseases which intravenously injected or orally administered treatments cannot reach due to the blood-brain barrier.
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