Comprehensive Metabolite Profile Uncovers the Bioactive Components, Antioxidant and Antibacterial Activities in Wild Tree Peony Leaves.
Comprehensive Metabolite Profile Uncovers the Bioactive Components, Antioxidant and Antibacterial Activities in Wild Tree Peony Leaves.
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DOI：
10.3390/ijms241310609
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发表时间：
2023-06-25
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
牡丹（学名：TreeploniaSectionMinglion），隶属于牡丹亚科（Vaginapae）和牡丹亚科（Delavayanae），共9个野生种，具有重要的观赏、营养和药用价值。本研究首次测定了9种野生牡丹新叶的生物活性成分、抗氧化活性和抑菌活性。通过非靶向代谢组学共鉴定出276种生物活性成分，其中80%以上为萜类和黄酮类化合物。共定量测定了42种差异代谢产物。主要的差异代谢产物为芍药苷、木犀草苷、金丝桃苷、芹菜素-7-葡萄糖苷、Rhoifolin和斑蝥素。这种高萜类化合物和黄酮类化合物含量的叶提取物使它们成为具有较强抗菌能力的物种，并且大多数测试的细菌显示出更大的敏感性，来自亚组阴道的成员比那些亚组Delavaypatient。所有WTPS都具有显着的抗氧化活性;这种活性归因于高水平的总酚含量（TPC）和总黄酮含量（TFC），其中，在九种WTPS中，黄紫菜的抗氧化能力最强。研究结果为牡丹叶在食品、医药等行业的深入应用提供了理论依据。
Tree peonies (Paeonia Section Moutan)—including nine wild species, which belong to subsections Vaginatae and Delavayanae—are economically important plants with ornamental, nutritional, and medicinal applications. In this study, for the first time, we determined the bioactive components and antioxidant activities and antibacterial activities of the newly grown leaves of nine wild tree peony species (WTPS). A total of 276 bioactive components were identified through non-targeted metabolomics; more than 80% of the 276 metabolites identified are terpenoids and flavonoids. A total of 42 differential metabolites were quantitatively determined. The main differential metabolites were Paeoniflorin, Luteoloside, Hyperin, Apigenin-7-glucoside, Rhoifolin, and Cantharidin. Such a high terpenoid and flavonoid content of the leaf extracts renders them as species with strong antibacterial capacities, and most of the bacteria tested showed greater sensitivity derived from the members of subsection Vaginatae than those of subsection Delavayanae. All WTPS have significant antioxidant activity; this activity is attributed to high levels of the total phenolic content (TPC) and total flavonoid content (TFC), of which, among the nine WTPS, P. lutea has the strongest antioxidant capacity. Our results provided a theoretical basis for the in-deep application of tree peony leaves for food, medical, and pharmaceutical industries.
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影响因子：
7.2
作者：
Martin-Vertedor, Daniel;Garrido, Maria;Delgado-Adamez, Jonathan
通讯作者：
Delgado-Adamez, Jonathan
影响因子：
6.1
作者：
Gericke, Sebastian;Luebken, Tilo;Speer, Karl
通讯作者：
Speer, Karl
影响因子：
6.1
作者：
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通讯作者：
Merillon, Jean-Michel
影响因子：
8.8
作者：
Lin, Jin-Yuarn;Tang, Ching-Yin
通讯作者：
Tang, Ching-Yin
影响因子：
5.2
作者：
Andrews, JM
通讯作者：
Andrews, JM