Thyroid hormones are associated with exposure to persistent organic pollutants in aging residents of upper Hudson River communities.
Thyroid hormones are associated with exposure to persistent organic pollutants in aging residents of upper Hudson River communities.
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DOI：
10.1016/j.ijheh.2013.09.003
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发表时间：
2014-04
影响因子：
6
通讯作者：
Fitzgerald, Edward F.
中科院分区：
文献类型：
--
作者：
Bloom, Michael S.;Jansing, Robert L.;Kannan, Kurunthachalam;Rej, Robert;Fitzgerald, Edward F.
关键词：
本研究的目的是评估人口老龄化中持久性有机污染物 (POP) 与甲状腺激素之间的关系。居住在哈德逊河上游社区的 48 名女性和 66 名男性，年龄在 55 岁至 74 岁之间，完成了一份调查问卷并提供了血液样本。分析血清中的促甲状腺素（促甲状腺激素，TSH）、游离甲状腺素（fT4）、总甲状腺素（T4）、总三碘甲状腺原氨酸（T3）以及 POP。持久性有机污染物包括 39 种多氯联苯 (PCB)、二氯二苯基三氯乙烷 (DDT) 和二氯二苯基二氯乙烯 (DDE)，通过电子捕获检测气相色谱 (GC-ECD) 测定，以及通过高分辨率气相色谱和高分辨率质谱检测 (HRGC-HRMS) 测定的 9 种多溴二苯醚 (PBDE)。使用多变量线性回归分析评估甲状腺激素与 POP 总数之间的关联，调整协变量并按性别分层。影响表现为与暴露水平加倍相关的甲状腺激素水平的差异。在女性中，DDT+DDE 使 T4 增加 0.34 μg/dL (P=0.04)，使 T3 增加 2.78 ng/dL (P=0.05)。同样在女性中，PCB 总量与 PBDE 结合导致 T3 增加 24.39-80.85 ng/dL (P<0.05)，PCB 总量与 DDT+DDE 结合导致 T4 增加 0.18-0.31 μg/dL (P<0.05)。对于男性，雌激素 PCB 与 T3 降低 19.82 ng/dL 相关（P=0.003），雌激素 PCB 与 DDT+DDE 联合使用导致 T3 降低 18.02 ng/dL（P=0.04）。鉴于与年龄相关的生理储备下降，持久性有机污染物对老年人群中甲状腺激素的影响可能具有临床意义，值得进一步研究。
The aim of this study was to evaluate the association between persistent organic pollutants (POPs), and thyroid hormones in an aging population. Forty-eight women and 66 men, aged 55 to 74 years and living in upper Hudson River communities completed a questionnaire and provided blood specimens. Serum was analyzed for thyrotropin (thyroid stimulating hormone, TSH), free (fT4) and total thyroxine (T4), total triiodothyronine (T3), and for POPs. POPs included 39 polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) determined by gas chromatography with electron capture detection (GC-ECD), and nine polybrominated diphenyl ethers (PBDEs) determined by high-resolution gas chromatography with high-resolution mass spectrometry detection (HRGC-HRMS). Multivariable linear regression analysis was used to evaluate associations between thyroid hormones and sums of POPs, adjusted for covariates and stratified by sex. Effects were expressed as differences in thyroid hormone levels associated with a doubling in the level of exposure. Among women, DDT+DDE increased T4 by 0.34 μg/dL (P=0.04) and T3 by 2.78 ng/dL (P=0.05). Also in women, sums of PCBs in conjunction with PBDEs elicited increases of 24.39-80.85 ng/dL T3 (P<0.05), and sums of PCBs in conjunction with DDT+DDE elicited increases of 0.18-0.31 μg/dL T4 (P<0.05). For men estrogenic PCBs were associated with a 19.82 ng/dL T3 decrease (P=0.003), and the sum of estrogenic PCBs in conjunction with DDT+DDE elicited an 18.02 ng/dL T3 decrease (P=0.04). Given age-related declines in physiologic reserve, the influence of POPs on thyroid hormones in aging populations may have clinical implications and merits further investigation.
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DOI：
10.1016/j.ijheh.2009.04.005
发表时间：
2009-11-01
影响因子：
6
作者：
Bloom, Michael S.;Vena, John E.;Kostyniak, Paul J.
通讯作者：
Kostyniak, Paul J.
影响因子：
2.2
作者：
HESCH, RD;GATZ, J;STUBBE, P
通讯作者：
STUBBE, P
影响因子：
3.4
作者：
Fitzgerald, Edward F.;Shrestha, Srishti;Hwang, Syni-an
通讯作者：
Hwang, Syni-an
影响因子：
6.6
作者：
Hagmar, L
通讯作者：
Hagmar, L
DOI：
10.1080/00039890109604065
发表时间：
2001-03-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Hagmar, L;Björk, J;Erfurth, EM
通讯作者：
Erfurth, EM