Summary of the Joint National Institutes of Health and the Food and Drug Administration Workshop Titled "Exploring the Science Surrounding the Safe Use of Bioactive Ingredients in Infant Formula: Considerations for an Assessment Framework".
Summary of the Joint National Institutes of Health and the Food and Drug Administration Workshop Titled "Exploring the Science Surrounding the Safe Use of Bioactive Ingredients in Infant Formula: Considerations for an Assessment Framework".
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DOI：
10.1016/j.jpeds.2022.11.027
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发表时间：
2023-04
影响因子：
5.1
通讯作者：
Neu, Josef
中科院分区：
文献类型：
--
作者：
Donovan, Sharon M.;Abrams, Steven A.;Azad, Meghan B.;Belfort, Mandy B.;Bode, Lars;Carlson, Susan E.;Dallas, David C.;Hettinga, Kasper;Jarvinen, Kirsi;Kim, Jae H.;Lebrilla, Carlito B.;McGuire, Michelle K.;Sela, David A.;Neu, Josef
美国政府和许多专业协会建议母乳是6个月以下婴儿的唯一营养来源。（1，2）然而，在美国，只有大约25%的婴儿达到这一目标，这表明迫切需要改善社会，社区和家庭之间的多层次支持母乳喂养。(2)此外，当母乳喂养是不可能的，获得一个安全和有效的营养来源，由婴儿配方奶粉（IF）提供的是至关重要的。学术机构、政府研究机构和工业界一直在寻找可以添加到配方奶粉中的人乳（HM）中的生物活性成分。(1)美国国家儿童健康和人类发展研究所（NICHD）制定了一项战略计划（https：//www.nichd.com）。nichd。nih。gov/about/org/strategicplan），它认识到在整个生命周期中最佳营养的重要性。一个理想的目标是通过优化配方以模仿人乳的组成来优化婴儿存活和健康。这是一个由美国国立卫生研究院和食品药品监督管理局赞助和组织的研讨会的摘要。研讨会的重点是关于被认为对婴儿具有生物活性的人乳成分的科学现状，并广泛思考如何评估已经包含或将来可能包含的成分作为婴儿配方奶粉成分的安全性。研讨会邀请了14位演讲者，他们在与哺乳、母乳成分、母乳成分生物活性以及临床哺乳学和儿科医学相关的基础研究方面具有广泛的专业知识。
The US government and many professional societies recommend that human milk be the sole source of nutrition for infants up to 6 months-of-age.(1, 2) However, only about 25% of infants in the United States meet this goal signaling an urgent need for improved multi-level support for breastfeeding among societies, communities, and families.(2) In addition, when breastfeeding is not possible, access to a safe and effective source of nutrition—provided by infant formula (IF) is critical. The search for bioactive ingredients found in human milk (HM) that could be added to formula has been intense among academic institutions, governmental research institutes, and industry.(1) The National Institutes of Child Health and Human Development (NICHD) developed a strategic plan (https://www. nichd. nih. gov/about/org/strategicplan) that recognizes the importance of optimal nutrition across the lifespan. One aspirational goal is to optimize infant survival and health by optimizing formulas to mimic the composition of HM. more closely.This is a summary of a workshop sponsored and organized by the United States National Institutes of Health and the Food and Drug Administration1. The workshop focused on the state of the science regarding what is known about human milk constituents that are thought to have bioactivity in infants and to think broadly about how to evaluate the safety of constituents that are already included or that could be included in the future as ingredients for use in infant formula. The workshop included 14 invited speakers with broad expertise in basic research related to lactation, human milk composition, bioactivity of human milk components and clinical neonatology and pediatric medicine.
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影响因子：
5.6
作者：
Beverly RL;Woonnimani P;Scottoline BP;Lueangsakulthai J;Dallas DC
通讯作者：
Dallas DC
影响因子：
7.1
作者：
Colombo, John;Carlson, Susan E.;Brez, Caitlin
通讯作者：
Brez, Caitlin
影响因子：
5.1
作者：
Beal, Jennifer;Silverman, Benson;Klontz, Karl
通讯作者：
Klontz, Karl
影响因子：
4.2
作者：
Comstock, Sarah S.;Li, Min;Donovan, Sharon M.
通讯作者：
Donovan, Sharon M.
影响因子：
2.7
作者：
Abrams, Steven A.;Schanler, Richard J.;Rechtman, David J.
通讯作者：
Rechtman, David J.