Height correlates with dyslipidemia in non-overweight middle-aged Japanese men.
Height correlates with dyslipidemia in non-overweight middle-aged Japanese men.
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DOI：
10.1186/s40101-016-0119-1
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发表时间：
2016-12-06
影响因子：
3.1
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Yoshimine H;Nagayoshi M;Kadota K;Takahashi K;Izumino K;Inoue K;Maeda T
我们之前的研究表明，身高与日本中年男性的中风风险呈负相关，尤其是那些体重指数（BMI）较低的男性。由于身高被认为是童年社会和身体状况的替代因素，而体重指数可能主要反映当前的身体状况，因此对体重指数较低的人进行详细分析可能会阐明童年状况的影响。另一方面，血脂异常被认为是心血管疾病的重要危险因素。然而，尚无研究报告身高与血脂异常之间的关系（影响体重指数）。我们对 3016 名 30-59 岁的日本男性进行了一项以医院为基础的一般人群横断面研究。日本动脉粥样硬化协会 (JAS) 指南对血脂异常的定义如下：甘油三酯 (TG) ≥ 150 mg/dL 和/或低密度脂蛋白胆固醇 (LDL) ≥ 140 mg/dL 和/或高密度脂蛋白胆固醇 (HDL)< 40 mg/dL 和/或脂质减少药物使用。独立于经典的心血管危险因素，BMI<25 kg/m2 的受试者中，身高与血脂异常呈负相关，但 BMI≥25 kg/m2 的受试者则不然。对于 BMI< 25 kg/m2 的受试者，身高 (5.7 cm) 每增加 1 个标准差 (SD)，调整后的血脂异常比值比 (OR) 和 95% 置信区间 (CI) 分别为 0.90 (0.82–0.99) 和 1.02 (0.89–1.17)。 BMI ≥ 25 kg/m2。对于 BMI< 25 kg/m2 的人来说，身高与血脂异常呈负相关，但与 BMI≥25 kg/m2 的人则不然。
Our previous study showed that height is inversely associated with the risk of stroke in middle-aged Japanese men, particularly in those with a low body mass index (BMI). Since height is regarded as a surrogate maker of childhood social and physical condition, while BMI may reflect primarily on the current physical condition, a detailed analysis of those with a lower BMI may elucidate the effects of childhood conditions. On the other hand, dyslipidemia is recognized as a prominent risk factor for cardiovascular disease. However, no studies have reported on the association between height and dyslipidemia accounting for BMI status. We conducted a hospital-based general population cross-sectional study of 3016 Japanese men aged 30–59 years. Dyslipidemia is defined by the Japan Atherosclerosis Society (JAS) Guidelines as follows: triglycerides (TG) ≥ 150 mg/dL and/or low-density lipoprotein-cholesterol (LDL) ≥ 140 mg/dL, and/or high-density lipoprotein-cholesterol (HDL) < 40 mg/dL, and/or lipid lowering medication use. Independent of classical cardiovascular risk factors, height was found to be inversely associated with dyslipidemia in subjects with a BMI <25 kg/m2 but not in subjects with a BMI ≥25 kg/m2. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of dyslipidemia for an increment of one standard deviation (SD) in height (5.7 cm) were 0.90 (0.82–0.99) for subjects with a BMI < 25 kg/m2 and 1.02 (0.89–1.17) for subjects with a BMI ≥ 25 kg/m2. Height is inversely associated with dyslipidemia in those with a BMI < 25 kg/m2 but not with a BMI ≥ 25 kg/m2.
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影响因子：
7.7
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
Teramoto, Tamio;Sasaki, Jun;Yokode, Masayuki
通讯作者：
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影响因子：
3.1
作者：
Shimizu Y;Nakazato M;Sekita T;Kadota K;Arima K;Yamasaki H;Goto H;Shirahama S;Takamura N;Aoyagi K;Maeda T
通讯作者：
Maeda T