Effects of Exercise Training on Neurotrophic Factors and Blood-Brain Barrier Permeability in Young-Old and Old-Old Women.
Effects of Exercise Training on Neurotrophic Factors and Blood-Brain Barrier Permeability in Young-Old and Old-Old Women.
复制标题
DOI：
10.3390/ijerph192416896
复制
发表时间：
2022-12-16
影响因子：
--
通讯作者：
Roh, Hee-Tae
中科院分区：
文献类型：
--
作者：
Cho, Su-Youn;Roh, Hee-Tae
衰老和定期锻炼可能对大脑健康产生相反的影响，尽管氧化应激和沉默调节素可能参与这些影响，但有关该主题的研究有限。因此，本研究旨在验证运动训练对中老年妇女氧化-抗氧化平衡、神经营养因子、血脑屏障通透性和sirtuins的影响。研究参与者为12名65-74岁的女性（年轻-老年组）和12名75-84岁的女性（老年-老年组）。所有被选中的参与者进行运动训练，包括跑步机步行和阻力带运动，每周三次，持续12周。在运动训练前后采集血样，分析血清氧化-抗氧化标志物（活性氧[ROS]、超氧化物歧化酶[SOD]）、神经营养因子（脑源性神经营养因子[BDNF]、血管内皮生长因子[VEGF]）水平和血脑屏障通透性标志物（S100钙结合蛋白β [S100β]、基质金属蛋白酶-9 [MMP-9]）水平和沉默调节蛋白（SIRT-1、SIRT-2、SIRT-3）水平。青年-老年组训练后SOD、BDNF、VEGF、SIRT-1和SIRT-3水平较训练前显著升高（p < 0.05），BDNF水平较老年-老年组显著升高（p < 0.05）。另一方面，与训练前的水平相比，老年-老年组在训练后显示出显著更高的SIRT-1水平（p < 0.05）。因此，运动训练可以有效地增加老年妇女的神经营养因子的水平和降低血脑屏障的通透性，并且抗氧化能力的增加和sirtuins水平的升高被认为在这些作用中起主要作用。运动的积极影响可能在相对年轻的参与者中更大。
Aging and regular exercise may have opposite effects on brain health, and although oxidative stress and sirtuins may be involved in these effects, studies on this topic are limited. Accordingly, the present study aimed to verify the effect of exercise training on oxidant–antioxidant balance, neurotrophic factors, blood–brain barrier permeability, and sirtuins in young-old and old-old women. The study participants were 12 women aged 65–74 years (Young-Old group) and 12 women aged 75–84 years (Old-Old group). All of the selected participants performed exercise training consisting of treadmill walking and resistance band exercise three times a week for 12 weeks. Blood samples were collected before and after exercise training to analyze serum oxidant–antioxidant markers (reactive oxygen species [ROS], superoxide dismutase [SOD]), neurotrophic factor (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor [VEGF]) levels, and blood–brain barrier permeability marker (S100 calcium-binding protein β [S100β], matrix metalloproteinase-9 [MMP-9]) levels, and sirtuin (SIRT-1, SIRT-2, SIRT-3) levels. The Young-Old group showed significantly increased SOD, BDNF, VEGF, SIRT-1, and SIRT-3 levels after training in comparison with the levels before training (p < 0.05), and a significantly higher BDNF level than the Old-Old group after training (p < 0.05). On the other hand, the Old-Old group showed significantly higher SIRT-1 levels after training in comparison with the levels before training (p < 0.05). Thus, exercise training may be effective in increasing the levels of neurotropic factors and reducing blood–brain barrier permeability in the elderly women, and increased antioxidant capacity and elevated levels of sirtuins are believed to play a major role in these effects. The positive effect of exercise may be greater in participants of relatively young age.
登录
查看更多内容
DOI：
10.3233/jad-160593
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Håkansson K;Ledreux A;Daffner K;Terjestam Y;Bergman P;Carlsson R;Kivipelto M;Winblad B;Granholm AC;Mohammed AK
通讯作者：
Mohammed AK
影响因子：
4.1
作者：
Carlos Venegas-Sanabria, Luis;Cavero-Redondo, Ivan;Martinez-Vizcaino, Vicente;Alberto Cano-Gutierrez, Carlos;Alvarez-Bueno, Celia
通讯作者：
Alvarez-Bueno, Celia
影响因子：
2.5
作者：
Bouzid, Mohamed Amine;Filaire, Edith;Fabre, Claudine
通讯作者：
Fabre, Claudine
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
Sirt1-Sirt3 轴调节人血脑屏障通透性以应对缺血
影响因子：
11.4
作者：
Chen T;Dai SH;Li X;Luo P;Zhu J;Wang YH;Fei Z;Jiang XF
通讯作者：
Jiang XF