Neurocognitive correlates of apathy and anxiety in Parkinson's disease.

Neurocognitive correlates of apathy and anxiety in Parkinson's disease.
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DOI:
10.1155/2012/793076
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发表时间:
2012
期刊:
Parkinson's disease
影响因子:
--
通讯作者:
Cronin-Golomb A
Cronin-Golomb A
中科院分区:
其他
文献类型:
--
作者:
Bogdanova Y;Cronin-Golomb A

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帕金森病(PD)与各种非运动症状有关,包括神经、精神和认知功能障碍。我们研究了帕金森病患者的冷漠、焦虑、运动症状的发作侧和认知之间的关系。我们假设帕金森病患者会根据发病侧的不同表现出不同的神经精神和神经认知特征。对22例非痴呆帕金森病患者(左侧11例,右侧11例)和22例健康对照(NC)进行冷漠和焦虑评定量表评定,并进行一系列神经心理测试。PD患者的焦虑水平明显高于正常对照组。冷漠、焦虑和病程之间有很大的关联。在LPD中,冷漠而不是焦虑与非语言中介执行功能和视觉空间测量的表现有关,而在RPD中,焦虑而不是冷漠与言语中介任务的表现相关。我们的发现表明,帕金森病患者的冷漠和焦虑与认知存在不同的联系。
Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD.
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