Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters.
Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters.
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DOI：
10.1016/j.reprotox.2018.02.008
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Louis GMB
中科院分区：
文献类型：
--
作者：
Smarr MM;Honda M;Kannan K;Chen Z;Kim S;Louis GMB
包括对羟基苯甲酸酯、三氯生和三氯卡班在内的抗菌剂具有内分泌干扰特性。在计划怀孕的夫妇的501名男性伴侣中，对羟基苯甲酸酯、三氯生和三氯卡班暴露的孕前尿液生物标志物在现场尿液样本中进行了定量。男性还提供了两个新鲜的精液样本，收集了大约一个月，进行24小时精液质量分析。采用线性混合效应模型，调整肌酐，种族，年龄和体重指数，以评估对数转换的化学浓度之间的关系，重新调整其标准差和精液参数。对羟基苯甲酸甲酯、乙酯和丁酯与精子计数减少和几个精子活力参数相关。羟基化对羟基苯甲酸酯代谢物和三氯生与选定的精液质量参数显著正相关。总的来说，我们的研究结果表明，在消费品中发现的特定尿中对羟基苯甲酸酯（甲基，乙基和丁基对羟基苯甲酸酯）可能会对试图怀孕的夫妇的育龄男性伴侣的精子质量参数产生不利影响。尿液化学物质浓度与精液参数之间的显著相关性。对羟基苯甲酸酯、三氯生和三氯卡班与精液质量参数之间存在显著相关性（p <0.05），其中↓和↑表示1个自然对数转换之间的负效应和正效应估计值，标准化了每个化学浓度和每个精液参数的标准差单位增加。橙子阴影的关联通常被认为与精液质量下降相关，而蓝色阴影的关联被认为暗示精液质量提高。模糊的解释（以白色突出显示）。
Antimicrobials including parabens, triclosan, and triclocarban have endocrine disrupting properties. Among 501 male partners of couples planning to become pregnant, preconception urinary biomarkers of parabens, triclosan and triclocarban exposure were quantified in spot urine samples. Men also provided two fresh semen samples collected approximately one month to undergo 24-hour semen quality analysis. Linear mixed-effects models, adjusted for creatinine, race, age and body mass index, were utilized to assess the relationship between log transformed chemical concentrations rescaled by their standard deviations and semen parameters. Methyl, ethyl and butyl parabens, were associated with diminished sperm count and several sperm motility parameters. Hydroxylated paraben metabolites and triclosan were significantly positively associated with select semen quality parameters. Overall, our findings suggest that specific urinary parabens found in consumer goods (methyl, ethyl and butyl parabens) may adversely impact sperm quality parameters among reproductive-age male partners of couples trying for pregnancy. Significant associations between urinary chemical concentrations and semen parameters. Significant associations (p<0.05) between parabens, triclosan, and triclocarban and semen quality parameters, with ↓ and ↑ indicating negative and positive effect estimates between 1 natural logtransformed, standardized the standard deviation unit increase for each chemical concentration and each semen parameter. Associations shaded in orange are generally thought to be associated with diminished semen quality, whereas associations shaded in blue are thought to suggestive enhanced semen quality. Nebulous interpretations (highlighted in white).
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影响因子：
10.4
作者：
Lubin JH;Colt JS;Camann D;Davis S;Cerhan JR;Severson RK;Bernstein L;Hartge P
通讯作者：
Hartge P
影响因子：
4.3
作者：
Oishi, S
通讯作者：
Oishi, S
DOI：
10.1016/j.reprotox.2015.02.002
发表时间：
2015-04
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Dodge LE;Kelley KE;Williams PL;Williams MA;Hernández-Díaz S;Missmer SA;Hauser R
通讯作者：
Hauser R
DOI：
10.1097/jom.0000000000001106
发表时间：
2017-11-01
影响因子：
3.2
作者：
Jurewicz, Joanna;Radwan, Michal;Hanke, Wojciech
通讯作者：
Hanke, Wojciech
影响因子：
11.4
作者：
Liao, Chunyang;Liu, Fang;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam