Cruciferous vegetable consumption and pancreatic cancer: A case-control study.
Cruciferous vegetable consumption and pancreatic cancer: A case-control study.
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DOI：
10.1016/j.canep.2021.101924
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发表时间：
2021-06
影响因子：
2.6
通讯作者：
Moysich KB
中科院分区：
文献类型：
--
作者：
Morrison MEW;Hobika EG;Joseph JM;Stenzel AE;Mongiovi JM;Tang L;McCann SE;Marshall J;Fountzilas C;Moysich KB
胰腺癌是一种致命的恶性肿瘤，筛查有限，可改变的危险因素也很少。本研究的目的是调查可改变的生活方式行为、十字花科蔬菜消费和胰腺癌之间的关联，包括总体和基于不可改变的既定危险因素的亚组。我们利用罗斯威尔公园综合癌症中心（纽约州布法罗）患者流行病学数据系统（1982-1998）的数据进行了一项以医院为基础的病例对照研究，其中包括 183 名胰腺癌患者和 732 名无癌症对照者。使用自填问卷收集数据，其中包括 52 项食物频率问卷和其他流行病学数据。使用多变量逻辑回归，根据年龄、体重指数 (BMI)、性别、吸烟状况、总肉类和胰腺癌家族史进行调整，用于估计十字花科蔬菜消费与胰腺癌之间关联的比值比 (OR) 和 95% 置信区间 (CI)。按性别、吸烟状况和体重指数进行亚组分析。我们观察到十字花科蔬菜摄入量与胰腺癌之间呈负相关，与每周食用生十字花科蔬菜 (SPW) 少于 0.5 份的受试者相比，每周食用 >1.5 份生十字花科蔬菜的受试者患胰腺癌的几率显着降低 40%（OR = 0.60，95% CI：0.39–0.93）。总的、生的和煮熟的十字花科蔬菜每增加一个 SPW，胰腺癌的发病率就会显着降低 7-15%，其中生十字花科蔬菜的相关性最强（OR = 0.85，95% CI：0.75-0.95）。我们观察到，在超重人群、戒烟者和男性中，生十字花科蔬菜摄入量与胰腺癌之间呈负相关，其发病率降低 50% 至 59%。食用十字花科蔬菜，尤其是生十字花科蔬菜，是一种可改变的生活方式，可能与胰腺癌呈负相关，包括具有其他不易改变的这种致命恶性肿瘤危险因素的亚组。
Pancreatic cancer is a deadly malignancy with limited screening and few modifiable risk factors. The objective of this study was to investigate the association between a modifiable lifestyle behavior, cruciferous vegetable consumption, and pancreatic cancer, both overall and by subgroups based on non-modifiable, established risk factors. We conducted a hospital-based, case-control study utilizing data from the Patient Epidemiology Data System (1982–1998) at Roswell Park Comprehensive Cancer Center (Buffalo, NY) which included 183 pancreatic cancer patients and 732 cancer-free controls. Data were collected using a self-administered questionnaire including a 52-item food frequency questionnaire and other epidemiologic data. Multivariable logistic regression, adjusted for age, body mass index (BMI), sex, smoking status, total meat, and family history of pancreatic cancer, was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations between cruciferous vegetable consumption and pancreatic cancer. Subgroup analyses were conducted by sex, smoking status, and BMI. We observed inverse associations between cruciferous vegetable intake and pancreatic cancer, with a significant 40% lower odds of pancreatic cancer among subjects consuming >1.5 servings per week (SPW) of raw cruciferous vegetables compared to those consuming less than 0.5 SPW (OR = 0.60, 95% CI: 0.39–0.93). Each additional SPW of total, raw, and cooked cruciferous vegetables was associated with a significant 7–15% lower odds of pancreatic cancer, with the strongest association seen in raw cruciferous vegetables (OR = 0.85, 95% CI: 0.75–0.95). We observed inverse associations between raw cruciferous vegetable intake and pancreatic cancer among people who were overweight, former smokers, and males, ranging from 50% to 59% lower odds. Consuming cruciferous vegetables, especially raw cruciferous vegetables, is a modifiable lifestyle behavior which may be inversely associated with pancreatic cancer, including among subgroups with other non- or not easily modifiable risk factors for this deadly malignancy.
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影响因子：
2.3
作者：
Anderson, Laura N.;Cotterchio, Michelle;Gallinger, Steven
通讯作者：
Gallinger, Steven
影响因子：
5.2
作者：
Casari I;Falasca M
通讯作者：
Falasca M
DOI：
10.1158/1055-9965.epi-10-0475
发表时间：
2010-10
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Lam TK;Ruczinski I;Helzlsouer KJ;Shugart YY;Caulfield LE;Alberg AJ
通讯作者：
Alberg AJ
影响因子：
3.7
作者：
Hua, Yong-Fei;Wang, Gao-Qing;Lu, Cai-De
通讯作者：
Lu, Cai-De
影响因子：
11.2
作者：
Gupta, Parul;Wright, Stephen E.;Kim, Sung-Hoon;Srivastava, Sanjay K.
通讯作者：
Srivastava, Sanjay K.