Neuropsychological profile of autism and the broad autism phenotype.
Neuropsychological profile of autism and the broad autism phenotype.
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DOI：
10.1001/archgenpsychiatry.2009.34
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发表时间：
2009-05
影响因子：
--
通讯作者：
Piven, Joseph
中科院分区：
文献类型：
--
作者：
Losh, Molly;Adolphs, Ralph;Poe, Michele D.;Couture, Shannon;Penn, David;Baranek, Grace T.;Piven, Joseph
现在有多份报告显示，亲属之间存在一系列语言、个性和社会行为特征，反映了自闭症的症状领域，但表现得要温和得多。对这种“广泛自闭症表型”（BAP）的研究可能提供一种潜在的重要的补充方法，用于检测导致自闭症的基因并定义相关的神经回路，通过识别更精确的表型，这些表型可以在受影响和未受影响的个体中定量测量，并且与大脑特定区域的功能有关。深入了解自闭症遗传易感性的神经心理学特征。病例对照一般社区。38名高功能自闭症患者和自闭症患者的父母，有和没有BAP（N=83），以及对照组。一个全面的神经心理学任务，利用社会认知，执行功能和全球/本地处理策略（中央一致性）。患有自闭症的个体和患有BAP的父母在社会认知的测量上与对照组不同，在其他两个领域的表现与对照组更相似。数据表明，社会认知领域可能是一个重要的目标，为联系表型认知过程的大脑结构在自闭症，并可能最终提供洞察基因参与自闭症。
There now exist multiple reports of a constellation of language, personality, and social-behavioral features present among relatives that mirror the symptom domains of autism, but much milder in expression. Studies of this ‘broad autism phenotype’ (BAP) may provide a potentially important, complementary approach for detecting the genes causing autism and defining associated neural circuitry, by identifying more refined phenotypes which can be measured quantitatively in both affected and unaffected individuals, and which are tied to functioning in particular regions of the brain. To gain insights into neuropsychological features that index genetic liability to autism. Case-control. General community. Thirty-eight high-functioning individuals with autism and parents of autistic individuals, both with and without the BAP (N=83), as well as control groups. A comprehensive battery of neuropsychological tasks tapping social cognition, executive function, and global/local processing strategies (central coherence). Both individuals with autism and parents with the BAP differed from controls on measures of social cognition, with performance in the other two domains more similar to controls. Data suggest that the social cognitive domain may be an important target for linking phenotype to cognitive process to brain structure in autism, and may ultimately provide insights into genes involved in autism.
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影响因子：
3.2
作者：
Adolphs, R;Tranel, D
通讯作者：
Tranel, D
影响因子：
3.4
作者：
DUNCAN, J
通讯作者：
DUNCAN, J
影响因子：
3.3
作者：
EISENBERG, L
通讯作者：
EISENBERG, L
影响因子：
3.2
作者：
Adolphs, R;Sears, L;Piven, J
通讯作者：
Piven, J
影响因子：
7.6
作者：
Happé, F;Briskman, J;Frith, U
通讯作者：
Frith, U