Chronic Ethanol Exposure during Adolescence Increases Voluntary Ethanol Consumption in Adulthood in Female Sprague Dawley Rats.
Chronic Ethanol Exposure during Adolescence Increases Voluntary Ethanol Consumption in Adulthood in Female Sprague Dawley Rats.
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DOI：
10.3390/brainsci10120900
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发表时间：
2020-11-24
期刊：
影响因子：
3.3
通讯作者：
Kirstein CL
中科院分区：
文献类型：
--
作者：
Maldonado-Devincci AM;Kirstein CL
由于青春期酒精使用量的急剧上升，早期饮酒是一个主要问题。在人类中，青春期的男性和女性的饮酒率相同；然而，成年后的男性更有可能摄入有害水平的酒精。在动物模型中，青春期酒精暴露的长期剂量依赖和性别依赖的影响，相对于成年后开始的暴露，还没有被容易地评估。这组实验的目的是确定青春期长期接触酒精是否会使成年后的雄性和雌性大鼠比那些直到成年早期才长期接触酒精的动物更容易摄入更多的乙醇。雄性和雌性大鼠在青春期(出生后30~50天)或成年期(出生后60~80天)分别慢性给予0.75g/kg或1.5g/kg乙醇或生理盐水21d。所有大鼠随后进行了14天的禁欲(分别为PND 51-或PND 81-94)。最后，所有的大鼠被给予每天30分钟的糖精加糖乙醇或单独的糖精，对于青少年暴露的大鼠是65-80 PND，对于成年暴露的大鼠是PND 95-110。暴露于0.75g/kg乙醇不会改变青少年暴露或成年暴露大鼠的乙醇或糖精摄入量，无论性别。相比之下，在青春期长期暴露于较高的1.5g/kg剂量会增加雌性大鼠成年后的酒精摄入量。然而，在青春期或成年期，接触1.5g/kg乙醇的动物的糖精摄入量没有变化，无论性别。此外，对于给予较高剂量乙醇的挑战，翻正反射丧失的持续时间和血液中的乙醇浓度没有明显的年龄和酒精依赖性变化。这组实验的结果表明，雌性大鼠在青春期长期接触高剂量的酒精确实会使大鼠在成年后摄入更多的酒精。鉴于这些影响只在青春期暴露的雌性大鼠中观察到，这些结果支持了雌性大鼠对青春期酒精暴露的长期后果的独特脆弱性，这种影响不仅仅是由乙醇溶液中使用的甜味剂介导的。
Early alcohol use is a major concern due to the dramatic rise in alcohol use during adolescence. In humans, adolescent males and females consume alcohol at equivalent rates; however, in adulthood males are more likely to consume harmful levels of alcohol. In animal models, the long-term dose-dependent and sex-dependent effects of alcohol exposure during adolescence have not been readily assessed relative to exposure that is initiated in adulthood. The purpose of the present set of experiments was to determine if adolescent exposure to chronic ethanol would predispose male and female rats to greater ethanol intake in adulthood when compared to animals that were not exposed to chronic ethanol exposure until early adulthood. Male and female rats were chronically administered 0.75 g/kg or 1.5 g/kg ethanol or saline for 21 days during adolescence (postnatal day (PND) 30–50) or adulthood (PND 60–80). All rats subsequently underwent 14-days of abstinence (PND 51–64 or PND 81–94, respectively). Finally, all rats were given 30-min daily access to saccharin-sweetened ethanol or saccharin alone from PND 65–80 for adolescent-exposed rats and PND 95–110 for adult-exposed rats. Exposure to 0.75 g/kg ethanol did not alter ethanol or saccharin intake in adolescent-exposed or adult-exposed rats, regardless of sex. In contrast, chronic exposure to the higher 1.5 g/kg dose during adolescence increased ethanol intake in adulthood in female rats. However, there was no change in saccharin intake in animals exposed to 1.5 g/kg ethanol during adolescence or adulthood, regardless of sex. Additionally, there were no clear age- and ethanol-dependent changes in duration of loss of righting reflex and blood ethanol concentrations to a challenge administration of a higher dose of ethanol. The results of the present set of experiments indicate chronic exposure to a high dose of ethanol during adolescence in female rats did indeed predispose rats to consume more ethanol in adulthood. Given that these effects were only observed in adolescent-exposed female rats, these results support a unique vulnerability to the long-term consequences of adolescent ethanol exposure in female rats, an effect that is not merely mediated by the sweetener used in the ethanol solution.
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影响因子：
2
作者：
Bolland, Kathleen A.;Bolland, John M.;Wimberly, Joshua C.
通讯作者：
Wimberly, Joshua C.
影响因子：
2.3
作者：
Hargreaves, Garth A.;Monds, Lauren;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
影响因子：
2.7
作者：
Land, C;Spear, NE
通讯作者：
Spear, NE
DOI：
10.1111/j.1530-0277.2008.00806.x
发表时间：
2008-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Dawson DA;Goldstein RB;Chou SP;Ruan WJ;Grant BF
通讯作者：
Grant BF
DOI：
10.1016/j.alcohol.2009.09.035
发表时间：
2010-02
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Maldonado-Devincci AM;Badanich KA;Kirstein CL
通讯作者：
Kirstein CL