Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry.
Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry.
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DOI：
10.1016/j.alcohol.2009.09.035
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Kirstein CL
中科院分区：
文献类型：
--
作者：
Maldonado-Devincci AM;Badanich KA;Kirstein CL
酒精使用在青少年时期增加，这在美国是一个令人担忧的问题。在人类中，男性和女性消耗不同数量的酒精取决于开始的年龄和早期乙醇消费的长期后果还不容易理解。我们工作的目的是更好地了解青春期乙醇暴露的直接和长期影响，以及它对行为和多巴胺能反应的影响。我们评估了青春期和成年期自愿酒精消费的性别差异以及青春期酒精暴露的影响。我们已经观察到，男性是敏感的被动的社会影响，介导自愿乙醇消费和早期乙醇暴露诱导长期变化的响应乙醇在成年期。暴露于中等剂量的乙醇在青春期产生的改变多巴胺（DA）在隔核（NAcc）在青春期和成年期以后。综上所述，所有这些数据表明，青少年的大脑在这个关键的发育时期对早期乙醇暴露的影响很敏感。
Alcohol use increases across adolescence and is a concern in the United States. In humans, males and females consume different amounts of alcohol depending on the age of initiation and the long-term consequences of early ethanol consumption are not readily understood. The purpose of our work is to better understand the immediate and long-term impact of ethanol exposure during adolescence and the effects it can have on behavior and dopaminergic responsivity. We have assessed sex differences in voluntary ethanol consumption during adolescence and adulthood and the influence of binge ethanol exposure during adolescence. We have observed that males are sensitive to passive social influences that mediate voluntary ethanol consumption and early ethanol exposure induces long-term changes in responsivity to ethanol in adulthood. Exposure to moderate doses of ethanol during adolescence produced alterations in dopamine (DA) in the nucleus accumbens septi (NAcc) during adolescence and later in adulthood. Taken together, all of these data indicate the adolescent brain is sensitive to the impact of early ethanol exposure during this critical developmental period.
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影响因子：
3.6
作者：
Fernández-Vidal, JM;Molina, JC
通讯作者：
Molina, JC
影响因子：
3.6
作者：
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作者：
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DOI：
10.1097/01.alc.0000183007.65998.aa
发表时间：
2005-10-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Almeida, OFX;Shoaib, M;Patchev, VK
通讯作者：
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