A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence.
A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence.
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DOI：
10.1016/j.schres.2013.09.021
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发表时间：
2014-01
影响因子：
4.5
通讯作者：
Jones, Peter B.
中科院分区：
文献类型：
--
作者：
Khandaker, Golam M.;Zammit, Stanley;Lewis, Glyn;Jones, Peter B.
关键词：
精神分裂症与特应性和炎症标志物增加有关。我们报告了一项基于人群的儿童特应性疾病、随后的血清炎症标志物、白细胞介素6 （IL-6）和c反应蛋白（CRP）与精神病经历（PEs）风险之间关联的纵向研究。pe在13岁时进行评估（n = 6785）。临床诊断的特应性疾病（哮喘和湿疹）的存在是通过父母在10岁时填写的问卷来确定的（n = 7814）。9岁时测定血清IL-6和CRP （n = 5076）。Logistic回归检验了(1)特应性与PEs之间的关系，(2)炎症标志物与PEs之间的关系，以及(3)炎症标志物对特应性- PEs关联的中介作用。线性回归检验了特应性和炎症标志物之间的关系。年龄、性别、社会阶层、种族和体重指数都是潜在的混杂因素。在10岁时，约14%的样本报告患有哮喘，12%患有湿疹，7%患有哮喘和湿疹。与没有特异反应的儿童相比，所有这些组在13岁时发生pe的风险都增加了；校正优势比（95% CI）分别为1.39（1.10-1.77）、1.33（1.04-1.69）和1.44（1.06-1.94）。特应性与血清IL-6和CRP升高有关；然而，这并没有介导特异性和pe之间的关联。炎症标志物与后来的pe无关。儿童特应性疾病增加了青少年精神病经历的风险。这些个体的随访将有助于确定特应性和炎症对早期pe不同轨迹的影响。
Schizophrenia is associated with atopy and increased inflammatory markers. We report a population-based longitudinal study of the associations between childhood atopic disorders, subsequent serum inflammatory markers, interleukin 6 (IL-6) and C-reactive protein (CRP), and the risk of psychotic experiences (PEs). PEs were assessed at age 13 years (n = 6785). Presence of clinician-diagnosed atopic disorders (asthma and eczema) was determined from parent-completed questionnaires at age 10 years (n = 7814). Serum IL-6 and CRP were measured at age 9 years (n = 5076). Logistic regression examined the association between (1) atopy and PEs, (2) inflammatory markers and PEs, and (3) mediating effects of inflammatory markers on the atopy–PEs association. Linear regression examined the association between atopy and inflammatory markers. Age, gender, social class, ethnicity and body mass index were included as potential confounders. At age 10 years, about 14% of the sample was reported to have asthma, 12% eczema, and 7% both asthma and eczema. Compared with children with no atopy, risk of PEs at age 13 years was increased for all of these groups; adjusted odds ratios (95% CI) were, respectively, 1.39 (1.10–1.77), 1.33 (1.04–1.69), and 1.44 (1.06–1.94). Atopy was associated with increased serum IL-6 and CRP; however, this did not mediate association between atopy and PEs. Inflammatory markers were not associated with later PEs. Childhood atopic disorders increase the risk of psychotic experiences in adolescence. Follow-up of these individuals will be useful to determine the effect of atopy and inflammation on different trajectories of early-life PEs.
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