Circadian rhythms and pancreas physiology: A review.
Circadian rhythms and pancreas physiology: A review.
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DOI：
10.3389/fendo.2022.920261
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发表时间：
2022
影响因子：
5.2
通讯作者：
Pearson, James Alexander
中科院分区：
文献类型：
--
作者：
Chan, Karl;Wong, F. Susan;Pearson, James Alexander
2型糖尿病、肥胖症和代谢综合征正在世界范围内变得更加普遍，并将给医疗保健系统带来越来越具有挑战性的负担。这些相互关联的代谢异常使受影响的个体容易出现过多的并发症和共病。此外，据世界卫生组织估计，2019年糖尿病导致了150万人死亡，预计这一数字在未来几年还会上升。这突出表明有必要对代谢性疾病及其并发症的管理进行进一步研究。对昼夜节律的研究，指的是大约每24小时重复一次的生理和行为变化，可能为管理代谢性疾病提供重要的见解。流行病学研究表明，夜班工人和经常长途飞行的人等面临昼夜节律紊乱风险的人群，也面临胰岛素抵抗和肥胖等代谢异常的风险增加。昼夜节律基因的异常表达似乎有助于代谢功能的失调，如胰岛素分泌、葡萄糖稳态和能量消耗。这些发现的潜在临床意义已经在动物研究和人类试点研究中得到强调，这些研究导致了包括计时疗法(时间特定疗法)、限时喂养和昼夜分子稳定剂/类似物在内的昼夜干预策略的发展。对这些领域的研究将为新陈代谢疾病的昼夜节律药物的未来提供洞察力。在这篇综述中，我们讨论了代谢的生理学和昼夜节律在调节这些代谢功能中的作用。此外，我们回顾了昼夜生理学的临床方面，以及正在进行的和未来的研究可能对代谢性疾病的管理产生的影响。
Type 2 diabetes mellitus, obesity and metabolic syndrome are becoming more prevalent worldwide and will present an increasingly challenging burden on healthcare systems. These interlinked metabolic abnormalities predispose affected individuals to a plethora of complications and comorbidities. Furthermore, diabetes is estimated by the World Health Organization to have caused 1.5 million deaths in 2019, with this figure projected to rise in coming years. This highlights the need for further research into the management of metabolic diseases and their complications. Studies on circadian rhythms, referring to physiological and behavioral changes which repeat approximately every 24 hours, may provide important insight into managing metabolic disease. Epidemiological studies show that populations who are at risk of circadian disruption such as night shift workers and regular long-haul flyers are also at an elevated risk of metabolic abnormalities such as insulin resistance and obesity. Aberrant expression of circadian genes appears to contribute to the dysregulation of metabolic functions such as insulin secretion, glucose homeostasis and energy expenditure. The potential clinical implications of these findings have been highlighted in animal studies and pilot studies in humans giving rise to the development of circadian interventions strategies including chronotherapy (time-specific therapy), time-restricted feeding, and circadian molecule stabilizers/analogues. Research into these areas will provide insights into the future of circadian medicine in metabolic diseases. In this review, we discuss the physiology of metabolism and the role of circadian timing in regulating these metabolic functions. Also, we review the clinical aspects of circadian physiology and the impact that ongoing and future research may have on the management of metabolic disease.
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影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
64.5
作者：
Balsalobre, A;Damiola, F;Schibler, U
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Schibler, U
DOI：
10.1152/ajpregu.1998.274.6.r1751
发表时间：
1998-06-01
影响因子：
2.8
作者：
Challet, E;Solberg, LC;Turek, FW
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Turek, FW
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U
DOI：
10.1152/ajpendo.1996.271.2.e246
发表时间：
1996-08-01
影响因子：
5.1
作者：
Boden, G;Ruiz, J;Chen, XH
通讯作者：
Chen, XH