Primate homologs of mouse cortico-striatal circuits
Primate homologs of mouse cortico-striatal circuits
复制标题
小鼠皮质纹状体回路的灵长类同源物
DOI：
10.1101/834481
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Balsters J
中科院分区：
文献类型：
--
作者：
Balsters J
随着生物医学研究中动物模型的必要性日益增加，迫切需要通过建立啮齿动物和灵长类动物神经解剖学的相似性和差异性来协调不同物种的研究结果。使用连接指纹匹配，我们比较了人类，非人类灵长类动物和小鼠的皮质-纹状体回路，使用所有物种的静息状态fMRI数据。我们的研究结果表明，连接模式的神经核和皮质-纹状体运动电路（后/外侧壳核）是保守的跨物种，使它们成为跨物种比较的可靠目标。然而，大量的人类和猕猴纹状体体素与任何小鼠皮质-纹状体回路都不匹配（小鼠->人类：85%未分配;小鼠->猕猴69%未分配;猕猴->人类; 31%未分配）。这些未分配的体素定位于尾状核和前壳核，与纹状体的执行功能和社会/语言区域重叠，并连接到前额叶投射的小脑小叶和前额叶皮层，形成似乎是非人类灵长类动物和人类独有的回路。
With the increasing necessity of animal models in biomedical research, there is a vital need to harmonise findings across species by establishing similarities and differences in rodent and primate neuroanatomy. Using connectivity fingerprint matching, we compared cortico-striatal circuits across humans, non-human primates, and mice using resting-state fMRI data in all species. Our results suggest that the connectivity patterns for the nucleus accumbens and cortico-striatal motor circuits (posterior/lateral putamen) were conserved across species, making them reliable targets for cross-species comparisons. However, a large number of human and macaque striatal voxels were not matched to any mouse cortico-striatal circuit (mouse->human: 85% unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned). These unassigned voxels were localised to the caudate nucleus and anterior putamen, overlapping with executive function and social/language regions of the striatum and connected to prefrontal-projecting cerebellar lobules and anterior prefrontal cortex, forming circuits that seem to be unique for non-human primates and humans.
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影响因子：
5.7
作者：
Van Essen, David C.;Smith, Stephen M.;Barch, Deanna M.;Behrens, Timothy E. J.;Yacoub, Essa;Ugurbil, Kamil
通讯作者：
Ugurbil, Kamil
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1093/cercor/bhy046
发表时间：
2018-07-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Zerbi V;Ielacqua GD;Markicevic M;Haberl MG;Ellisman MH;A-Bhaskaran A;Frick A;Rudin M;Wenderoth N
通讯作者：
Wenderoth N
影响因子：
3.7
作者：
Steele, C. J.;Anwander, A.;Villringer, A.
通讯作者：
Villringer, A.
影响因子：
2.5
作者：
SAINTCYR, JA;UNGERLEIDER, LG;DESIMONE, R
通讯作者：
DESIMONE, R