Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study.

Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study.
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DOI:
10.1111/ijpo.12277
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发表时间:
2018-08
期刊:
影响因子:
3.8
通讯作者:
SWIFT Offspring Study Investigators
SWIFT Offspring Study Investigators
中科院分区:
医学3区
文献类型:
--
作者:
Gunderson EP;Greenspan LC;Faith MS;Hurston SR;Quesenberry CP Jr;SWIFT Offspring Study Investigators

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母乳喂养(BF)可以防止肥胖和2型糖尿病的儿童暴露于母体糖尿病在子宫内,但其对婴儿生长的影响在这个高风险群体中很少被评估。本研究的目的是评估BF强度和持续时间与婴儿生长的关系,从出生到12个月的母亲与妊娠期糖尿病(GDM)的后代。464例GDM母婴配对的前瞻性队列(28%白色,36%西班牙裔,26%亚洲人,8%黑人,2%其他)。出生时、6-9周、6个月和12个月时测量体重和身长。在6-9周(研究基线)时分类为强化BF或配方奶粉喂养(FF)组,从出生到12个月的强度为第1组:一致排除/大部分FF,第2组:在3-9个月内从BF过渡到FF,第3组:一致排除/大部分BF。多变量混合线性回归模型估计了z评分的校正平均值(95%置信区间)变化;身高体重(WLZ)、年龄体重和年龄身高。与6-9周时的强化BF相比,FF显示从6 - 9周至6个月的WLZ评分增加更大[+0.38(0.13至0.62)vs. +0.02(-0.15至0.19); p = 0.02]和出生至12个月[+1.11(0.87至1.34)vs. +0.53(0.37至0.69); p < 0.001]。对于12个月的强度和持续时间,第2组和第3组从6周至9周至6个月的WLZ评分增幅小于第1组[-0.05(−0.27至0.18)和+0.07(-0.19至0.23)与+0.40(0.15至0.64); p = 0.01和0.07],出生至12个月[+0.60(0.39至0.82)和+0.59(0.33至0.85)对比+0.97(0.75至1.19); p < 0.05]。在GDM母亲的后代中,从出生到1岁的高强度BF与婴儿体重增长较慢和体重增加较低有关。
Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated. The objective of this study was to evaluate BF intensity and duration in relation to infant growth from birth through 12 months among offspring of mothers with gestational diabetes mellitus (GDM). Prospective cohort of 464 GDM mother-infant dyads (28% White, 36% Hispanic, 26% Asian, 8% Black, 2% other). Weight and length measured at birth, 6–9 weeks, 6 months and 12 months. Categorized as intensive BF or formula feeding (FF) groups at 6–9 weeks (study baseline), and intensity from birth through 12 months as Group 1: consistent exclusive/mostly FF, Group 2: transition from BF to FF within 3–9 months and Group 3: consistent exclusive/mostly BF. Multivariable mixed linear regression models estimated adjusted mean (95% confidence interval) change in z-scores; weight-for-length (WLZ), weight-for-age and length-for-age. Compared with intensive BF at 6–9 weeks, FF showed greater increases in WLZ-scores from 6 to 9 weeks to 6 months [+0.38 (0.13 to 0.62) vs. +0.02 (−0.15 to 0.19); p = 0.02] and birth to 12 months [+1.11 (0.87 to 1.34) vs. +0.53 (0.37 to 0.69); p < 0.001]. For 12-month intensity and duration, Groups 2 and 3 had smaller WLZ-score increases than Group 1 from 6 to 9 weeks to 6 months [−0.05 (−0.27 to 0.18) and +0.07 (−0.19 to 0.23) vs. +0.40 (0.15 to 0.64); p = 0.01 and 0.07], and birth to 12 months [+0.60 (0.39 to 0.82) and +0.59 (0.33 to 0.85) vs. +0.97 (0.75 to 1.19); p < 0.05]. Among offspring of mothers with GDM, high intensity BF from birth through 1 year is associated with slower infant ponderal growth and lower weight gain.
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发表时间: 1981-01-01
期刊: ACTA PAEDIATRICA SCANDINAVICA
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期刊: PEDIATRIC OBESITY
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