Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets.
Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets.
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DOI：
10.1289/ehp.5754
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发表时间：
2003-03
影响因子：
10.4
通讯作者：
Elgethun K
中科院分区：
文献类型：
--
作者：
Curl CL;Fenske RA;Elgethun K
我们通过生物监测评估了西雅图、华盛顿学龄前儿童从饮食中接触有机磷（OP）农药的情况。父母在收集尿液前3天保持食物日记，他们根据标签信息区分有机和传统食物。然后根据日记数据的分析，将儿童分为食用有机或传统饮食的儿童。还记录了每个家庭的住宅杀虫剂使用情况。我们收集了18名有机饮食儿童和21名常规饮食儿童的24小时尿液样本，并分析了五种OP农药代谢物。我们发现总二甲基烷基磷酸盐代谢物的中位浓度显著高于总二乙基烷基磷酸盐代谢物（分别为0.06和0.02 μ mol/L; p = 0.0001）。常规饮食儿童的总二甲基代谢物浓度中位数约为有机饮食儿童的6倍（0.17和0.03 μ mol/L; p = 0.0003）;平均浓度相差9倍（0.34和0.04 μ mol/L）。我们根据尿中二甲基代谢物和农业农药使用数据计算了剂量估计值，假设所有暴露均来自单一农药。剂量估计表明，有机水果，蔬菜和果汁的消费可以将儿童的暴露水平从高于美国环境保护署现行指南的水平降低到低于美国环境保护署现行指南的水平，从而将暴露从一系列不确定的风险转移到一系列可忽略的风险。有机产品的消费似乎为父母提供了一个相对简单的方法来减少他们的孩子接触有机磷农药。
We assessed organophosphorus (OP) pesticide exposure from diet by biological monitoring among Seattle, Washington, preschool children. Parents kept food diaries for 3 days before urine collection, and they distinguished organic and conventional foods based on label information. Children were then classified as having consumed either organic or conventional diets based on analysis of the diary data. Residential pesticide use was also recorded for each home. We collected 24-hr urine samples from 18 children with organic diets and 21 children with conventional diets and analyzed them for five OP pesticide metabolites. We found significantly higher median concentrations of total dimethyl alkylphosphate metabolites than total diethyl alkylphosphate metabolites (0.06 and 0.02 micro mol/L, respectively; p = 0.0001). The median total dimethyl metabolite concentration was approximately six times higher for children with conventional diets than for children with organic diets (0.17 and 0.03 micro mol/L; p = 0.0003); mean concentrations differed by a factor of nine (0.34 and 0.04 micro mol/L). We calculated dose estimates from urinary dimethyl metabolites and from agricultural pesticide use data, assuming that all exposure came from a single pesticide. The dose estimates suggest that consumption of organic fruits, vegetables, and juice can reduce children's exposure levels from above to below the U.S. Environmental Protection Agency's current guidelines, thereby shifting exposures from a range of uncertain risk to a range of negligible risk. Consumption of organic produce appears to provide a relatively simple way for parents to reduce their children's exposure to OP pesticides.
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影响因子：
2.5
作者：
Moate, TF;Lu, C;Kalman, DA
通讯作者：
Kalman, DA
影响因子：
10.4
作者：
Fenske, RA;Kissel, JC;Keifer, MC
通讯作者：
Keifer, MC
DOI：
10.1038/sj.jea.7500129
发表时间：
2000-11-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Akland, GG;Pellizzari, ED;Berry, MR
通讯作者：
Berry, MR
DOI：
10.1038/sj.jea.7500197
发表时间：
2002-01-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Fenske, RA;Kedan, G;Curl, CL
通讯作者：
Curl, CL
影响因子：
10.4
作者：
Lu, CS;Knutson, DE;Fenske, RA
通讯作者：
Fenske, RA