First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA.
First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA.
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DOI：
10.1007/s10995-012-1028-5
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发表时间：
2013-04
影响因子：
2.3
通讯作者：
Ritz B
中科院分区：
文献类型：
--
作者：
Lee PC;Roberts JM;Catov JM;Talbott EO;Ritz B
尽管有许多关于空气污染和不良出生结局的研究，但很少有研究调查先兆子痫和妊娠期高血压，这两种妊娠疾病对母亲和婴儿都有严重后果。根据医院出生记录，我们进行了一项队列研究，确定了1997年至2002年间在宾夕法尼亚州匹兹堡的Magee-Women医院分娩的34,705名单胎婴儿。采用时空普通克里格插值法估算妊娠前期颗粒物（<10 μm-PM10; <2.5 μm-PM2.5）和臭氧（O3）暴露浓度。我们采用多元logistic回归估计妊娠早期暴露与先兆子痫、妊娠高血压、早产和小于胎龄儿（SGA）之间的关联。PM2.5和O3曝光与子痫前期(调整或= 1.15,95% CI -1.39 = 0.96 / 4.0μg / m3 PM2.5增加;调整或= 1.12,95% CI -1.42 = 0.89 / O3)增加十亿分之16.8,妊娠高血压(PM2.5或= 1.11,95% CI = 1.00 - -1.23, O3或= 1.12,95% CI = 0.97 - -1.29),和早产(PM2.5口服补液盐= 1.10,95% CI = 1.01 - -1.20, O3口服补液盐= 1.23,95% CI = 1.01 - -1.50)。PM10与妊娠期高血压和SGA的风险也有较小的5 - 8%的增加，但没有子痫前期。我们的数据表明，孕早期暴露于颗粒，主要是PM2.5和臭氧，可能会增加患先兆子痫和妊娠高血压的风险，以及早产和SGA的风险。
Despite numerous studies of air pollution and adverse birth outcomes, few studies have investigated preeclampsia and gestational hypertension, two pregnancy disorders with serious consequences for both mother and infant. Relying on hospital birth records, we conducted a cohort study identifying 34,705 singleton births delivered at Magee-Women’s Hospital in Pittsburgh, PA between 1997 and 2002. Particle (<10 μm-PM10; <2.5 μm-PM2.5) and ozone (O3) exposure concentrations in the first trimester of pregnancy were estimated using the space–time ordinary Kriging interpolation method. We employed multiple logistic regression estimate associations between first trimester exposures and preeclampsia, gestational hypertension, preterm delivery, and small for gestational age (SGA) infants. PM2.5 and O3 exposures were associated with preeclampsia (adjusted OR = 1.15, 95 % CI = 0.96–1.39 per 4.0 μg/m3 increase in PM2.5; adjusted OR = 1.12, 95 % CI = 0.89–1.42 per 16.8 ppb increase in O3), gestational hypertension (for PM2.5 OR = 1.11, 95 % CI = 1.00–1.23; for O3 OR = 1.12, 95 % CI = 0.97–1.29), and preterm delivery (for PM2.5 ORs = 1.10, 95 % CI = 1.01–1.20; for O3 ORs = 1.23, 95 % CI = 1.01–1.50). Smaller 5–8 % increases in risk were also observed for PM10 with gestational hypertension and SGA, but not preeclampsia. Our data suggest that first trimester exposure to particles, mostly PM2.5, and ozone, may increase the risk of developing preeclampsia and gestational hypertension, as well as preterm delivery and SGA.
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