The prevalence of preterm birth and season of conception.
The prevalence of preterm birth and season of conception.
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DOI：
10.1111/j.1365-3016.2008.00971.x
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发表时间：
2008-11
影响因子：
2.8
通讯作者：
Simhan HN
中科院分区：
文献类型：
--
作者：
Bodnar LM;Simhan HN
早产是一个主要的产科问题。探索与早产有关的受孕季节可能为寻找危险因素提供方向。我们对1995年至2005年在宾夕法尼亚州匹兹堡市麦基妇女医院分娩的61630名妇女进行了82213例单胎活产（妊娠20-45周）的回顾性队列研究。根据最佳产科估计确定的胎龄估计受孕。傅立叶级数分析用于模拟季节趋势。孕37周以内的自发性早产与受孕季节有关（P < 0.05）。发病高峰出现在冬季和春季（2月23日达到6.9%的峰值），平均低谷出现在夏末/初秋（8月25日为6.2%）。<32周的自发性早产的模式相似（P < 0.05），3月13日为高峰（1.7%），9月12日为最低点（1.4%）。当包括早产时，结果相似。这些季节性变化可能会增加我们对早产病理生理学中季节性周期性暴露的作用的了解。
Preterm birth is a major obstetric problem. An exploration of the season of conception in relation to preterm birth may provide direction in the search for risk factors. We conducted a retrospective cohort study of 82 213 singleton livebirths (20–45 weeks’ gestation) to 61 630 women at Magee-Womens Hospital, Pittsburgh, PA, from 1995 to 2005. Conception was estimated based on gestational age determined by best obstetric estimate. Fourier series analysis was used to model seasonal trends. Spontaneous preterm birth at <37 weeks was associated with conception season (P < 0.05). The peak prevalence occurred among conceptions in winter and spring (peaking February 23 at 6.9%), with an average trough among late summer/early autumn conceptions (August 25 at 6.2%). The pattern for spontaneous preterm birth <32 weeks was similar (P < 0.05), with the peak on March 13 (1.7%), and nadir on September 12 (1.4%). Results were similar when indicated preterm births were included. These seasonal changes may increase our insight into the role of exposures with seasonal periodicity in the pathophysiology of preterm birth.
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