The Neurocircuitry Underlying Additive Effects of Safety Instruction on Extinction Learning.
The Neurocircuitry Underlying Additive Effects of Safety Instruction on Extinction Learning.
复制标题
DOI：
10.3389/fnbeh.2020.576247
复制
发表时间：
2020
影响因子：
3
通讯作者：
Diwadkar VA
中科院分区：
文献类型：
--
作者：
Javanbakht A;Grasser LR;Madaboosi S;Chowdury A;Liberzon I;Diwadkar VA
消亡学习是暴露疗法的主要实验室模式，这种疗法既包括对令人恐惧的物体附近的安全体验，也包括由治疗师传达的安全说明。虽然灭绝学习的经验性方面已经得到了很好的研究，但对指导性灭绝学习及其神经回路却知之甚少。在这里，我们研究了14名健康参与者的神经关联，以及指示消亡学习引发的网络互动。在对两个CS+刺激进行恐惧条件反射后，受试者被告知其中一个CS+S刺激(指令CS；CS+I)没有厌恶的无条件刺激(US)，但第二个CS+刺激(非指令CS+；CS+U)没有。在消退学习的早期，在vmPFC、dmPFC、VLPFC和右侧副海马区，CS+I>；CS+U对比区被观察到更大的激活。随后，应用心理生理相互作用(PPI)来研究vmPFC中种子的功能连通性。这项分析揭示了dmPFC、副海马体、杏仁核和脑岛的显著调制。我们的发现表明，在消亡学习过程中，认知指导的加入会导致情绪调节和重新评估网络的更大激活。这项工作是推进实验室范例的一步，实验室范例可以更准确地模拟暴露疗法，并确定可能成为神经调节以增强心理治疗效果的潜在靶点的区域。
Extinction learning is the dominant laboratory model for exposure therapy, a treatment involving both experience of safety near the feared object, and safety instructions relayed by a therapist. While the experiential aspect of extinction learning is well researched, less is known about instructed extinction learning and its neurocircuitry. Here, in 14 healthy participants we examined the neural correlates of, and the network interactions evoked by instructed extinction learning. Following fear conditioning to two CS+ stimuli, participants were instructed about the absence of the aversive unconditioned stimulus (US) for one of the CS+s (instructed CS; CS+I) but not the second CS+ (uninstructed CS+; CS+U). Early during extinction learning, greater activation was observed for the CS+I > CS+U contrast in regions including the vmPFC, dmPFC, vlPFC, and right parahippocampus. Subsequently, psychophysiological interaction (PPI) was applied to investigate functional connectivity of a seed in the vmPFC. This analyses revealed significant modulation of the dmPFC, parahippocampus, amygdala, and insula. Our findings suggest that the addition of cognitive instruction yields greater activation of emotion regulation and reappraisal networks during extinction learning. This work is a step in advancing laboratory paradigms that more accurately model exposure therapy and identifies regions which may be potential targets for neuromodulation to enhance psychotherapy effects.
登录
查看更多内容
影响因子：
9.2
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
5.7
作者：
Baldassano, Christopher;Beck, Diane M.;Fei-Fei, Li
通讯作者：
Fei-Fei, Li
DOI：
10.1037/0278-7393.3.5.608
发表时间：
1977-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN LEARNING AND MEMORY
影响因子：
--
作者：
HUGDAHL, K;OHMAN, A
通讯作者：
OHMAN, A
影响因子：
2.9
作者：
Ganella, Despina E.;Barendse, Marjolein E. A.;Whittle, Sarah
通讯作者：
Whittle, Sarah
DOI：
10.1016/j.jbtep.2015.06.003
发表时间：
2016-03-01
影响因子：
1.8
作者：
Cameron, Gemma;Roche, Bryan;Dymond, Simon
通讯作者：
Dymond, Simon