Cardiac dysfunction and hypothalamic activation during a social crowding stressor in prairie voles.
Cardiac dysfunction and hypothalamic activation during a social crowding stressor in prairie voles.
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DOI：
10.1016/j.autneu.2010.03.003
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发表时间：
2010-08-25
影响因子：
2.7
通讯作者：
Trahanas, Diane M.
中科院分区：
文献类型：
--
作者：
Grippo, Angela J.;Sgoifo, Andrea;Mastorci, Francesca;McNeal, Neal;Trahanas, Diane M.
关键词：
草原田鼠社交拥挤应激过程中的心脏功能障碍和下丘脑激活。 – 消极的社会互动会对人类和非人类动物产生多种有害后果；相反，积极的社交互动可能对行为和生理产生压力缓冲作用。然而，社会环境背景下特定压力源反应的机制尚不清楚。本研究调查了暴露于先前长期配对（对照条件）或隔离的雌性、社会一夫一妻制草原田鼠在急性社会应激源期间下丘脑室旁核的行为、心脏功能和 Fos 免疫反应性的整合。与先前暴露于社会配对的动物相比，先前暴露于社会隔离的动物在急性拥挤应激源期间表现出心率增加、心率变异性减弱以及心律失常的发生率增加；这些心脏变化并非继发于拥挤压力源期间的行为变化。此外，与社交配对相比，社交隔离与拥挤应激源后下丘脑室旁核的 c-Fos 免疫反应性增加有关。草原田鼠为理解社会环境如何影响人类行为、心脏功能和中枢压力调节过程的变化提供了一个有用的模型。
Cardiac dysfunction and hypothalamic activation during a social crowding stressor in prairie voles. – Negative social interactions produce several detrimental consequences in humans and non-human animals; and conversely, positive social interactions may have stress-buffering effects on both behavior and physiology. However, the mechanisms underlying specific stressor-responsiveness in the context of the social environment are not well understood. The present study investigated the integration of behavior, cardiac function, and Fos-immunoreactivity in the hypothalamic paraventricular nucleus during an acute social stressor in female, socially monogamous prairie voles exposed to previous long-term pairing (control conditions) or isolation. Animals previously exposed to social isolation displayed increased heart rate, attenuated heart rate variability, and increased incidence of cardiac arrhythmias during an acute crowding stressor versus animals previously exposed to social pairing; these cardiac alterations were not secondary to behavioral changes during the crowding stressor. Furthermore, social isolation was associated with increased c-Fos-immunoreactivity in the hypothalamic paraventricular nucleus following the crowding stressor, versus social pairing. The prairie vole provides a useful model for understanding how the social environment contributes to changes in behavior, cardiac function, and central stress-regulatory processes in humans.
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影响因子：
3.5
作者：
CARTER, CS;WITT, DM;VOLKENING, D
通讯作者：
VOLKENING, D
影响因子：
10.6
作者：
Grippo, Angela J.;Lamb, Damon G.;Porges, Stephen W.
通讯作者：
Porges, Stephen W.
影响因子：
3.7
作者：
Grippo, Angela J.;Gerena, Davida;Carter, C. Sue
通讯作者：
Carter, C. Sue
DOI：
10.1038/npp.2008.154
发表时间：
2009-05
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/j.cbpa.2005.09.014
发表时间：
2005-12-01
影响因子：
2.3
作者：
Djordjevic, J;Cvijic, G;Davidovic, V
通讯作者：
Davidovic, V