Understanding the burden of human papillomavirus-associated anal cancers in the US.
Understanding the burden of human papillomavirus-associated anal cancers in the US.
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DOI：
10.1002/cncr.23744
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发表时间：
2008-11-15
期刊：
影响因子：
6.2
通讯作者：
Cress, Rosemary D.
中科院分区：
文献类型：
--
作者：
Joseph, Djenaba A.;Miller, Jacqueline W.;Wu, Xiaocheng;Chen, Vivien W.;Morris, Cyllene R.;Goodman, Marc T.;Villalon-Gomez, Jose M.;Williams, Melanie A.;Cress, Rosemary D.
肛门癌在美国是一种不常见的恶性肿瘤；高达93%的肛门癌与人类乳头瘤病毒有关。分析了1998至2003年间39个以人群为基础的癌症登记处诊断的病例。分析包括下列肛门癌组织：鳞状细胞癌、腺癌和小细胞/神经内分泌癌。发病率根据2000年美国标准人口的年龄进行调整。从1998年到2003年，经年龄调整的侵袭性肛门癌年发病率为每10万人1.5例。鳞状细胞癌(SCC)是最常见的组织学类型，占21,395例(84.6%)肛门癌中的18,105例。女性的鳞癌发病率(1.5/100,000)高于男性(1.0)。白人和黑人的发病率最高(1.3)，而亚洲人/太平洋岛民(API)的发病率最低(0.3)。肛门鳞癌的发病率平均每年增加2.6%。大多数鳞癌的诊断是在原位或局限性阶段(58.1%)。API被诊断为地区性或远期疾病的可能性高于其他种族/民族(分别为27.5%和11.8%)。在所有疾病阶段，男性的5年相对存活率都低于女性。肛门鳞癌的发生率因性别、种族和民族而异。在地区/远程阶段诊断的API比例较高。男性的5年存活率低于女性。需要继续监测和进一步研究，以评估HPV疫苗对美国肛门癌负担的潜在影响。
Anal cancer is an uncommon malignancy in the US; up to 93% of anal cancers are associated with human papillomavirus. Cases diagnosed between 1998 and 2003 from 39 population-based cancer registries were analyzed. The following anal cancer histologies were included in the analysis: squamous cell, adenocarcinoma, and small cell/neuroendocrine carcinomas. Incidence rates were age-adjusted to the 2000 US standard population. From 1998 through 2003, the annual age-adjusted invasive anal cancer incidence rate was 1.5 per 100,000 persons. Squamous cell carcinoma (SCC) was the most common histology overall, accounting for 18,105 of 21,395 (84.6%) cases of anal cancer. Women had a higher rate of SCC (1.5 per 100,000) than men (1.0). Whites and blacks had the highest incidence rate (1.3), whereas Asians/Pacific Islanders (API) had the lowest rate (0.3). Incidence rates of anal SCC increased 2.6% per year on average. The majority of SCC cases were diagnosed at the in situ or localized stage (58.1%). API were more likely to be diagnosed with regional or distant stage disease than were other racial/ethnic groups (27.5% and 11.8%, respectively). Males had lower 5-year relative survival than females for all stages of disease. Rates of anal SCC varied by sex, race, and ethnicity. A higher proportion of API were diagnosed at regional/distant stage. Men had lower 5-year survival rates than women. Continued surveillance and additional research are needed to assess the potential impact of the HPV vaccine on the anal cancer burden in the US.
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影响因子：
14.5
作者：
Melbye, M;Frisch, M
通讯作者：
Frisch, M
影响因子：
3.8
作者：
Moscicki, AB;Durako, SJ;Wilson, CM
通讯作者：
Wilson, CM
影响因子：
5
作者：
DALING, JR;SHERMAN, KJ;WEISS, NS
通讯作者：
WEISS, NS
影响因子：
29.4
作者：
HOLMES, F;BOREK, D;HOLMES, G
通讯作者：
HOLMES, G
影响因子：
10.3
作者：
Frisch, M;Biggar, IJ;Goedert, JJ
通讯作者：
Goedert, JJ