Circadian rhythm disturbances in depression.
Circadian rhythm disturbances in depression.
复制标题
抑郁症中的昼夜节律障碍。
DOI：
10.1002/hup.964
复制
发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Kupfer DJ
中科院分区：
文献类型：
--
作者：
Germain A;Kupfer DJ
本文的目的是综述了解昼夜节律和睡眠节律的机制及其在抑郁症发病和治疗中的作用的进展。文献主要是通过Medline搜索选择的，其他报告是根据作者实验室正在进行的研究活动确定的。许多生理过程表现出昼夜节律的活动。睡眠和清醒是哺乳动物最明显的昼夜节律。有相当多的证据表明，昼夜节律和睡眠障碍在情绪障碍的病理生理学中很重要。抑郁症患者通常表现出昼夜节律改变、睡眠障碍和昼夜情绪变化。时间疗法，包括强光暴露、睡眠剥夺和社会节律疗法，可能是非季节性和季节性抑郁症的有用辅助手段。抗抑郁药物对昼夜节律和睡眠有显著影响。在了解时间生物学和睡眠调节机制方面的最新进展可能为开发治疗情绪障碍的新的药物和行为治疗策略提供新的见解和途径。
The aim of this article is to review progress in understanding the mechanisms that underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of depression. Literature was selected principally by Medline searches, and additional reports were identified based on ongoing research activities in the authors’ laboratory. Many physiological processes show circadian rhythms of activity. Sleep and waking are the most obvious circadian rhythms in mammals. There is considerable evidence that circadian and sleep disturbances are important in the pathophysiology of mood disorders. Depressed patients often show altered circadian rhythms, sleep disturbances, and diurnal mood variation. Chronotherapies, including bright light exposure, sleep deprivation, and social rhythm therapies, may be useful adjuncts in non-seasonal and seasonal depression. Antidepressant drugs have marked effects on circadian processes and sleep. Recent progress in understanding chronobiological and sleep regulation mechanisms may provide novel insights and avenues into the development of new pharmacological and behavioral treatment strategies for mood disorders.
登录
查看更多内容
影响因子：
11.3
作者：
Brown, LF;Reynolds, CF;Kupfer, DJ
通讯作者：
Kupfer, DJ
DOI：
10.1007/bf02900200
发表时间：
1997-04-01
影响因子：
4.7
作者：
Benedetti, F;Barbini, B;Smeraldi, E
通讯作者：
Smeraldi, E
影响因子：
5.4
作者：
Barbini, B;Benedetti, F;Smeraldi, E
通讯作者：
Smeraldi, E
影响因子：
5.3
作者：
Benedetti, F;Colombo, C;Smeraldi, E
通讯作者：
Smeraldi, E
影响因子：
4
作者：
Buijs, RM;van Eden, CG;Kalsbeek, A
通讯作者：
Kalsbeek, A