Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention.
Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention.
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DOI：
10.1007/s10549-017-4576-y
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发表时间：
2018-03
影响因子：
3.8
通讯作者：
Mittelman SD
中科院分区：
文献类型：
--
作者：
Dieli-Conwright CM;Parmentier JH;Sami N;Lee K;Spicer D;Mack WJ;Sattler F;Mittelman SD
肥胖是乳腺癌死亡率的一个可改变的主要因素，因为它与复发率增加和总生存率下降有关。肥胖通过白色脂肪组织中的慢性、低度炎症刺激癌症进展，导致脂肪组织巨噬细胞(ATM)、特别是促炎M1表型巨噬细胞的积累。运动已被证明可以减少肥胖成人的 M1 ATM 并增加更具抗炎作用的 M2 ATM。本研究的目的是确定 16 周的运动干预是否会积极改变肥胖绝经后乳腺癌幸存者的 ATM 表型。 20 名肥胖绝经后乳腺癌幸存者被随机分配接受为期 16 周的有氧运动和抗阻运动 (EX) 干预或延迟干预控制 (CON)。 EX组参加了为期16周的监督锻炼课程，每周3次。参与者在基线和 16 周研究期后提供了空腹血液、双能 X 射线吸收测定法 (DXA) 和浅层皮下腹部脂肪组织活检。 EX 参与者的身体成分、心脏代谢生物标志物和全身炎症均显着改善（与 CON 相比，所有 p<0.03）。 EX参与者的脂肪组织显示ATM M1显着减少（p<0.001），ATM M2增加（p<0.001），脂肪组织抗炎细胞因子如脂联素的分泌增加，促炎细胞因子IL-6和TNF-α的分泌减少（均p<0.055）。为期 16 周的有氧运动和抗阻运动干预可减轻肥胖绝经后乳腺癌幸存者的脂肪组织炎症。未来的大型随机试验有必要研究运动引起的脂肪组织炎症减少和乳腺癌复发的影响。
Obesity is a leading modifiable contributor to breast cancer mortality due to its association with increased recurrence and decreased overall survival rate. Obesity stimulates cancer progression through chronic, low-grade inflammation in white adipose tissue, leading to accumulation of adipose tissue macrophages (ATMs), in particular the pro-inflammatory Ml phenotype macrophage. Exercise has been shown to reduce M1 ATMs and increase the more anti-inflammatory M2 ATMs in obese adults. The purpose of this study was to determine whether a 16-week exercise intervention would positively alter ATM phenotype in obese postmenopausal breast cancer survivors. Twenty obese postmenopausal breast cancer survivors were randomized to a 16-week aerobic and resistance exercise (EX) intervention or delayed intervention control (CON). The EX group participated in 16 weeks of supervised exercise sessions 3 times/week. Participants provided fasting blood, dual-energy X-ray absorptiometry (DXA), and superficial subcutaneous abdominal adipose tissue biopsies at baseline and following the 16-week study period. EX participants experienced significant improvements in body composition, cardiometabolic biomarkers, and systemic inflammation (all p<0.03 vs CON). Adipose tissue from EX participants showed a significant decrease in ATM M1 (p<0.001), an increase in ATM M2 (p<0.001), increased adipose tissue secretion of anti-inflammatory cytokines such as adiponectin, and decreased secretion of the pro-inflammatory cytokines IL-6 and TNF- α (all p<0.055). A 16-week aerobic and resistance exercise intervention attenuates adipose tissue inflammation in obese postmenopausal breast cancer survivors. Future large randomized trials are warranted to investigate the impact of exercise-induced reductions in adipose tissue inflammation and breast cancer recurrence.
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影响因子：
120.1
作者：
Cao, Yihai
通讯作者：
Cao, Yihai
影响因子：
3.3
作者：
Campbell, Kristin L.;Foster-Schubert, Karen E.;Ulrich, Cornelia M.
通讯作者：
Ulrich, Cornelia M.
DOI：
10.1249/01.mss.0000175857.84936.1a
发表时间：
2005-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Hutnick, NA;Williams, NI;Mastro, AM
通讯作者：
Mastro, AM
影响因子：
254.7
作者：
Rock, Cheryl L.;Doyle, Colleen;Gansler, Ted
通讯作者：
Gansler, Ted
影响因子：
2.1
作者：
Ergun, M.;Eyigor, S.;Uslu, R.
通讯作者：
Uslu, R.