The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case-control study.
The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case-control study.
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DOI：
10.3389/fpubh.2023.1145113
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发表时间：
2023
影响因子：
5.2
通讯作者：
Zhang, Hongling
中科院分区：
文献类型：
--
作者：
Liu, Yuanxia;Chen, Hongmei;Zhang, Mengtian;Zhu, Gangjiao;Yang, Yan;Li, Yuanyuan;Lu, Wei;Zhang, Hongling
关键词：
硒（Se）是人体必需的微量元素。血清硒和尿硒也是评估硒暴露状况的生物标志物。然而，关注尿硒与妊娠期糖尿病（GDM）风险之间关系的研究很少。探讨尿硒与妊娠期糖尿病的关系。本研究采用巢式病例对照研究方法，以武汉地区的一个前瞻性出生队列为研究对象，探讨产前环境因素暴露对孕妇和儿童健康的影响。纳入226例病例和452例对照。在诊断GDM前采集孕妇尿标本，测定尿硒水平。我们以孕妇尿硒水平为分类变量，通过条件逻辑回归评估尿硒与GDM的相关性，并通过多元线性回归估计硒与血糖水平之间的相关性。还评估了母体年龄和胎儿性别的潜在修饰作用。尿硒水平较低与GDM的高风险显著相关（三分位数1的OR = 2.35，95%CI：1.36-4.06;三分位数2的校正OR = 1.79，95%CI：1.09-2.95;趋势p = 0.01）。胎儿性别与硒在GDM发病中存在交互作用。这种关联在怀女性胎儿的孕妇中比怀男性胎儿的孕妇中更明显。我们的研究表明，尿硒和GDM的风险之间存在显着的负相关性，这种关联可能取决于胎儿性别。
Selenium (Se) is an essential trace element for the human body. Serum Se and urinary Se are also biomarkers to assess Se exposure status. However, studies focusing on the association between urinary Se and the risk of gestational diabetes mellitus (GDM) are rare. To investigate the association between urinary Se and the risk of GDM. A nested case–control study based on a prospective birth cohort in Wuhan, China, which focuses on the effects of prenatal environmental factors exposure on pregnant women and children’s health was conducted. Two hundred and twenty-six cases and 452 controls were included. Maternal urine samples were collected before GDM diagnosis, and the urinary Se levels were determined. We assessed the association of urinary Se with GDM by conditional logistic regression with maternal urinary Se level as a categorical variable, and estimated the association between Se and glucose levels by multiple linear regression. The potential modifier roles of maternal age and fetal sex have also been assessed. Lower urinary level of Se was significantly associated with a higher risk of GDM (OR = 2.35 for the tertile 1, 95% CI:1.36-4.06; adjusted OR = 1.79 for the tertile 2, 95%CI:1.09-2.95; p for trend = 0.01). Fetal sex had an interaction with Se in the association with GDM. The association was more pronounced among pregnant women with female fetuses than with male fetuses. Our study suggested a significant negative association between urinary Se and the risk of GDM, and this association may vary depending on the fetal sex.
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