Voluntary aerobic exercise increases the cognitive enhancing effects of working memory training.
Voluntary aerobic exercise increases the cognitive enhancing effects of working memory training.
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DOI：
10.1016/j.bbr.2013.09.012
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Matzel, Louis D.
中科院分区：
文献类型：
--
作者：
Smith, Andrew M.;Spiegler, Kevin M.;Sauce, Bruno;Wass, Christopher D.;Sturzoiu, Tudor;Matzel, Louis D.
在注意力和学习测试中的表现通常在有氧运动后不久就能观察到，有证据表明，经常锻炼的人可以部分防止与年龄相关的认知能力下降。然而，运动的认知益处通常是短暂的，限制了这些观察结果的实际应用。我们探讨了如果体育锻炼与工作记忆训练相结合，体育锻炼是否会引起一般认知能力的持久变化，工作记忆训练据称会对认知表现产生广泛影响。小鼠接受锻炼（六周的自愿跑步轮访问），工作记忆训练，两种治疗或各种对照治疗。接近完成这一时期的运动，开始工作记忆训练（在双径向臂迷宫中）（与运动日交替），并持续数周。在完成这些处理后，评估动物在四种不同学习任务上的表现（2-4周后），并估计个体动物在所有四种学习任务中的总体表现。单独的工作记忆训练促进了一般认知表现的小幅增加，尽管单独锻炼的任何有益影响在学习评估时已经消失。然而，这两种治疗方法的结合使仅工作记忆训练支持的一般认知表现的改善增加了一倍以上。与急性有氧运动对孤立学习任务的短暂影响不同，这些结果表明，急性运动与工作记忆训练相结合，可以对一般认知表现产生协同和持久的影响。
Increases in performance on tests of attention and learning are often observed shortly after a period of aerobic exercise, and evidence suggests that humans who engage in regular exercise are partially protected from age-related cognitive decline. However, the cognitive benefits of exercise are typically short-lived, limiting the practical application of these observations. We explored whether physical exercise would induce lasting changes in general cognitive ability if that exercise was combined with working memory training, which is purported to broadly impact on cognitive performance. Mice received either exercise (six weeks of voluntary running wheel access), working memory training, both treatments, or various control treatments. Near the completion of this period of exercise, working memory training (in a dual radial-arm maze) was initiated (alternating with days of exercise), and was continued for several weeks. Upon completion of these treatments, animals were assessed (2–4 weeks later) for performance on four diverse learning tasks, and the aggregate performance of individual animals across all four learning tasks was estimated. Working memory training alone promoted small increases in general cognitive performance, although any beneficial effects of exercise alone had dissipated by the time of learning assessments. However, the two treatments in combination more than doubled the improvement in general cognitive performance supported by working memory training alone. Unlike the transient effects that acute aerobic exercise can have on isolated learning tasks, these results indicate that an acute period of exercise combined with working memory training can have synergistic and lasting impact on general cognitive performance.
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DOI：
10.1016/j.cub.2010.02.034
发表时间：
2010-04-27
期刊：
Current biology : CB
影响因子：
--
作者：
Light KR;Kolata S;Wass C;Denman-Brice A;Zagalsky R;Matzel LD
通讯作者：
Matzel LD
影响因子：
4.1
作者：
Redick, Thomas S.;Shipstead, Zach;Engle, Randall W.
通讯作者：
Engle, Randall W.
影响因子：
4.2
作者：
DUSTMAN, RE;RUHLING, RO;BRADFORD, DC
通讯作者：
BRADFORD, DC
影响因子：
2.5
作者：
Ekstrand, Joakim;Hellsten, Johan;Tingstrom, Anders
通讯作者：
Tingstrom, Anders
影响因子：
4.2
作者：
Holmes, MM;Galea, LAM;Kempermann, G
通讯作者：
Kempermann, G