Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations.
Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations.
复制标题
DOI：
10.1038/s41598-017-14769-z
复制
发表时间：
2017-11-06
影响因子：
4.6
通讯作者：
Leendertz FH
中科院分区：
文献类型：
--
作者：
Köndgen S;Calvignac-Spencer S;Grützmacher K;Keil V;Mätz-Rensing K;Nowak K;Metzger S;Kiyang J;Lübke-Becker A;Deschner T;Wittig RM;Lankester F;Leendertz FH
将野生类人猿用于旅游和研究的习惯化对这些物种的保护产生了重大的积极影响。然而，已查明与这些活动有关的风险，特别是将人类呼吸道病毒传播给野生类人猿，造成高发病率，有时甚至造成死亡。在这里，我们调查了在几次呼吸道疾病爆发过程中野生和圈养黑猩猩社区中细菌-病毒共感染的来源。分子生物学分析表明，人呼吸道合胞病毒（HRSV）和人偏肺病毒（HMPV）参与了该病的病因。此外，我们的分析提供了与链球菌（S.）肺炎。从野生黑猩猩身上分离出的细菌特征表明这些细菌来自人类。这些细菌的传播是令人关注的，因为与HRSV和HMPV相反，S。肺炎可以成为鼻咽植物群的一部分，导致呼吸道疾病进展的严重性。此外，这些细菌有可能传播到社区中的其他个体，并最终进入人群。有针对性的疫苗接种计划可用于为习惯性的类人猿接种疫苗，也可用于类人猿栖息地周围的人群接种疫苗，为人类和野生类人猿带来健康益处。
Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease. In addition our analysis provide evidence for coinfection with Streptococcus (S.) pneumoniae. Characterisation of isolates from wild chimpanzees point towards a human origin of these bacteria. Transmission of these bacteria is of concern because – in contrast to HRSV and HMPV - S. pneumoniae can become part of the nasopharyngeal flora, contributing to the severity of respiratory disease progression. Furthermore these bacteria have the potential to spread to other individuals in the community and ultimately into the population. Targeted vaccination programs could be used to vaccinate habituated great apes but also human populations around great ape habitats, bringing health benefits to both humans and wild great apes.
登录
查看更多内容
影响因子：
2.5
作者：
Gruetzmacher, Kim S.;Koendgen, Sophie;Leendertz, Fabian H.
通讯作者：
Leendertz, Fabian H.
DOI：
10.3181/00379727-127-32875
发表时间：
1968-01-01
影响因子：
--
作者：
DICK, EC
通讯作者：
DICK, EC
影响因子：
3.7
作者：
Denapaite D;Hakenbeck R
通讯作者：
Hakenbeck R
影响因子：
5.9
作者：
Leendertz, Fabian H.;Pauli, Georg;Boesch, Christophe
通讯作者：
Boesch, Christophe
DOI：
10.1093/bioinformatics/bts199
发表时间：
2012-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Kearse M;Moir R;Wilson A;Stones-Havas S;Cheung M;Sturrock S;Buxton S;Cooper A;Markowitz S;Duran C;Thierer T;Ashton B;Meintjes P;Drummond A
通讯作者：
Drummond A