Differences in the neuronal response to food in obesity-resistant as compared to obesity-prone individuals.
Differences in the neuronal response to food in obesity-resistant as compared to obesity-prone individuals.
复制标题
DOI：
10.1016/j.physbeh.2013.01.002
复制
发表时间：
2013-02-17
影响因子：
2.9
通讯作者：
Tregellas JR
中科院分区：
文献类型：
--
作者：
Cornier MA;McFadden KL;Thomas EA;Bechtell JL;Eichman LS;Bessesen DH;Tregellas JR
尽管生活在致肥胖的环境中，但与大多数有体重增加和肥胖风险的人相比，一些人仍保持苗条的表型。了解这些不同表型如何调节能量摄入至关重要。本研究的目的是根据自我认同、BMI 和个人/家庭体重史，检查被招募为抗肥胖 (OR) 或易肥胖 (OP) 的成年人对视觉食物线索的神经元反应的差异。在摄入 4 天的无热量能量后，对 25 名 OR 和 28 名 OP 个体进行了研究。功能磁共振成像 (fMRI) 在禁食和急性进食状态（测试餐后 30 分钟）进行，同时受试者观看高享乐价值的食物和中性非食物物体的图像。在测试餐前和测试餐后每 30 分钟使用视觉模拟量表测量食欲，持续 3 小时。在禁食状态下，与非食物图像相比，食物在 OR 和 OP 中引起岛叶、体感皮层、顶叶皮层和视觉皮层的显着反应。急性进食状态导致手术室个体的这些和其他大脑区域显着减弱，但OP个体则没有。此外，与 OR 个体相比，OP 个体对测试餐的反应显示出内侧和前额叶皮层 (PFC) 更大的激活。调整脂肪量不会影响这些结果。在进食状态下，岛叶/PFC 对食物图像的反应减弱与饥饿程度的更大程度减少有关。这些发现表明，体重增加和肥胖倾向的个体改变了已知对能量摄入调节很重要的大脑区域对食物信号的神经元反应。这些改变的反应可能代表了导致能量摄入过多和肥胖风险的重要机制。
Despite living in an obesogenic environment, some individuals maintain a thin phenotype compared to the majority who are at risk for weight gain and obesity. Understanding how these different phenotypes regulate energy intake is critical. The objective of this study was to examine the differences in neuronal response to visual food cues in adults recruited as either obesity-resistant (OR) or obesity-prone (OP) based on self-identification, BMI, and personal/family weight history. 25 OR and 28 OP individuals were studied after 4 days of eucaloric energy intake. Functional magnetic resonance imaging (fMRI) was performed in the fasted and acute fed states (30 minutes after a test meal) while subjects viewed images of foods of high hedonic value and neutral non-food objects. Measures of appetite using visual analog scales were performed before and every 30 minutes after the test meal for 3 hours. In the fasted state, food as compared to nonfood images elicited significant response in the insula, somatosensory cortex, parietal cortex, and visual cortex in both OR and OP. The acute fed state resulted in significant attenuation of these and other brain areas in the OR but not OP individuals. Furthermore, OP as compared to OR individuals showed greater activation of medial and anterior prefrontal cortex (PFC) in response to the test meal. Adjusting for fat mass did not impact these results. Attenuation of insula/PFC response to food images in the fed state was associated with greater reductions in hunger. These findings suggest that individuals prone to weight gain and obesity have altered neuronal responses to food cues in brain regions known to be important in energy intake regulation. These altered responses may represent an important mechanism contributing to excess energy intake and risk for obesity.
登录
查看更多内容
影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
DOI：
10.1186/1479-5868-8-101
发表时间：
2011-09-25
影响因子：
8.7
作者：
Burger, Kyle S.;Cornier, Marc A.;Johnson, Susan L.
通讯作者：
Johnson, Susan L.
影响因子：
7.1
作者：
Cornier, Marc-Andre;Von Kaenel, Sandra S.;Tregellas, Jason R.
通讯作者：
Tregellas, Jason R.
影响因子：
2.9
作者：
Cornier, Marc-Andre
通讯作者：
Cornier, Marc-Andre
影响因子：
3.4
作者：
Konishi, S;Nakajima, K;Miyashita, Y
通讯作者：
Miyashita, Y