Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community.
Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community.
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DOI：
10.1021/es4018688
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发表时间：
2013-10-01
影响因子：
11.4
通讯作者：
Eskenazi, Brenda
中科院分区：
文献类型：
--
作者：
Gunier, Robert B.;Bradman, Asa;Jerrett, Michael;Smith, Donald R.;Harley, Kim G.;Austin, Christine;Vedar, Michelle;Arora, Manish;Eskenazi, Brenda
锰（Mn）是一种必需的营养素，但过量摄入可能具有神经毒性。加州每年施用的含锰杀菌剂超过80万kg。牙齿中的锰水平是围产期暴露的一个有前途的生物标志物。我们分析的参与者包括207名参加萨利纳斯母亲和儿童健康评估中心（CHAMACOS）的儿童，这是一项在加州农业区进行的纵向出生队列研究。锰测量牙齿中使用激光烧蚀电感耦合等离子体质谱。我们的目的是确定环境和生活方式的因素与产前锰水平脱落的牙齿。我们发现，在家中存放农场工人的鞋子，母亲的农场工作，在住所3公里内使用含锰杀菌剂，住所建在安提阿壤土上，怀孕期间锰粉尘负荷（μg/m2地板面积）与产前牙本质中较高的锰水平相关（p < 0.05）。母亲孕期吸烟与产前牙本质锰含量呈负相关（p < 0.01）。多元回归模型解释了22-29%的变异性锰在产前牙本质。我们的研究结果表明，锰测量产前牙本质提供了回顾性和特定时间的胎儿暴露水平造成的环境和职业来源。
Manganese (Mn) is an essential nutrient, but overexposure can be neurotoxic. Over 800 000 kg of Mn-containing fungicides are applied each year in California. Manganese levels in teeth are a promising biomarker of perinatal exposure. Participants in our analysis included 207 children enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal birth cohort study in an agricultural area of California. Mn was measured in teeth using laser-ablation-inductively coupled plasma-mass spectrometry. Our purpose was to determine environmental and lifestyle factors related to prenatal Mn levels in shed teeth. We found that storage of farmworkers’ shoes in the home, maternal farm work, agricultural use of Mn-containing fungicides within 3 km of the residence, residence built on Antioch Loam soil and Mn dust loading (μg/m2 of floor area) during pregnancy were associated with higher Mn levels in prenatal dentin (p < 0.05). Maternal smoking during pregnancy was inversely related to Mn levels in prenatal dentin (p < 0.01). Multivariable regression models explained 22–29% of the variability of Mn in prenatal dentin. Our results suggest that Mn measured in prenatal dentin provides retrospective and time specific levels of fetal exposure resulting from environmental and occupational sources.
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影响因子：
10.4
作者：
Gunier RB;Ward MH;Airola M;Bell EM;Colt J;Nishioka M;Buffler PA;Reynolds P;Rull RP;Hertz A;Metayer C;Nuckols JR
通讯作者：
Nuckols JR
影响因子：
3.5
作者：
Colosio, C;Fustinoni, S;Maroni, M
通讯作者：
Maroni, M
DOI：
10.1038/jes.2008.18
发表时间：
2009-01-01
影响因子：
4.5
作者：
Bradman, Asa;Salvatore, Alicia L.;Eskenazi, Brenda
通讯作者：
Eskenazi, Brenda
影响因子：
11.4
作者：
Eastman, Rachel R.;Jursa, Tom P.;Benedetti, Chiara;Lucchini, Roberto G.;Smith, Donald R.
通讯作者：
Smith, Donald R.
影响因子：
3.4
作者：
Kim, Yangho;Lee, Byung-Kook
通讯作者：
Lee, Byung-Kook