Novel Bioactive Glass-Modified Hybrid Composite Resin: Mechanical Properties, Biocompatibility, and Antibacterial and Remineralizing Activity.
Novel Bioactive Glass-Modified Hybrid Composite Resin: Mechanical Properties, Biocompatibility, and Antibacterial and Remineralizing Activity.
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新型生物活性玻璃改性杂化复合树脂：机械性能、生物相容性、抗菌和再矿化活性
DOI：
10.3389/fbioe.2021.661734
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发表时间：
2021
影响因子：
5.7
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Han X;Chen Y;Jiang Q;Liu X;Chen Y
继发龋严重限制了复合树脂的使用寿命。然而，整合所有期望的特性（即，机械、抗菌、生物活性和生物相容性）结合到一种复合树脂中仍然具有挑战性。在此，一种新型的生物活性玻璃（BAG）改性杂化复合树脂已成功地开发，同时实现优异的机械性能，良好的生物相容性，抗菌和生物矿化能力。当BAG颗粒的质量分数为8 ~ 23 wt %时，在不影响转化率的前提下，对复合树脂的弯曲强度和压缩强度等力学性能没有明显影响。虽然在复合树脂中掺入质量分数为16wt%至23wt%的BAG会降低细胞活力，但通过调节pH值可以使活力恢复正常。此外，所获得的BAG改性的复合树脂表现出良好的抗变形链球菌的抗菌效果，并随着BAG颗粒的掺入而增强对脱矿牙本质表面的再矿化活性。其抑菌和生物活性的可能机制与生物活性离子（Ca ~（2+）、Si ~（4+））的释放密切相关，表明其抑菌和生物活性可以通过调节生物活性离子的量来控制。该复合树脂具有良好的力学性能、细胞毒性、抗菌活性和生物活性，具有良好的临床应用前景。我们的研究结果为生物活性复合树脂的更好设计和智能制造提供了见解。
Secondary caries seriously limits the lifetime of composite resin. However, integrating all desirable properties (i.e., mechanical, antibacterial, bioactivity, and biocompatibility) into one composite resin is still challenging. Herein, a novel bioactive glass (BAG)-modified hybrid composite resin has been successfully developed to simultaneously achieve excellent mechanical properties, good biocompatibility, and antibacterial and remineralizing capabilities. When the mass fractions of BAG particles were added from 8 to 23 wt %, the original mechanical properties of the composite resin, including flexural strength and compressive strength, were not obviously affected without compromising the degree of conversion. Although the BAG incorporation of mass fractions of 16 wt % to 23 wt % in composite resins reduced cell viability, the viability could be recovered to normal by adjusting the pH value. Moreover, the BAG-modified composite resins that were obtained showed good antibacterial effects against Streptococcus mutans and enhanced remineralizing activity on demineralized dentin surfaces with increasing incorporation of BAG particles. The possible mechanisms for antibacterial and remineralizing activity might be closely related to the release of bioactive ions (Ca2+, Si4+), suggesting that its antibacterial and biological properties can be controlled by modulating the amounts of bioactive ions. The capability to balance the mechanical properties, cytotoxicity, antibacterial activity, and bioactivity makes the BAG-modified composite resin a promising prospect for clinical application. Our findings provide insight into better design and intelligent fabrication of bioactive composite resins.
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影响因子：
5
作者：
Al-eesa, N. A.;Karpukhina, N.;Wong, F. S. L.
通讯作者：
Wong, F. S. L.
影响因子：
1.4
作者：
Kilic, Duygu;Kesim, Servet;Ozturk, Ahmet
通讯作者：
Ozturk, Ahmet
DOI：
10.3390/ma11020326
发表时间：
2018-02-24
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Drago L;Toscano M;Bottagisio M
通讯作者：
Bottagisio M
影响因子：
9.5
作者：
He, Jianliang;Zhu, Xiaodan;Tang, Zisheng
通讯作者：
Tang, Zisheng
影响因子：
7.6
作者：
Aponso, S.;Ummadi, J. G.;Koley, D.
通讯作者：
Koley, D.