Age differences in functional brain networks associated with loneliness and empathy.
Age differences in functional brain networks associated with loneliness and empathy.
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DOI：
10.1162/netn_a_00293
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发表时间：
2023
影响因子：
4.7
通讯作者：
Spreng, R. Nathan
中科院分区：
文献类型：
--
作者：
Mwilambwe-Tshilobo, Laetitia;Setton, Roni;Bzdok, Danilo;Turner, Gary R. R.;Spreng, R. Nathan
孤独感与大型网络内部和之间的静息状态功能连接（RSFC）差异有关。然而，社会性和成年后期大脑功能之间的年龄相关变化尚未得到很好的理解。在这里，我们研究了社会的两个维度——孤独和共情反应——与大脑皮层的RSFC之间的关联的年龄差异。在整个年轻人（平均年龄22.6岁，n = 128）和老年人（平均年龄69.0岁，n = 92）的样本中，孤独感和同理心的自我报告测量呈负相关。通过多回声fMRI RSFC的多变量分析，我们发现了与孤独和共情反应相关的个体和年龄组差异的不同功能连接模式。年轻人的孤独感和两个年龄组的共情与视觉网络与关联网络（如默认、额顶叶控制）的更大整合有关。孤独感与老年人网络内、网络间的关联整合呈正相关。这些结果扩展了我们之前在早期和中年人群中发现的结果，表明与孤独以及同理心相关的大脑系统在老年人中有所不同。此外，研究结果表明，在人类一生的发展过程中，社会经验的这两个方面涉及不同的神经认知过程。当一个人对人际关系的渴望或需要没有得到满足时，孤独感就会出现。这种感知到的社会孤立状态会影响社会认知过程，而社会认知过程对于与他人联系至关重要，比如同理心。神经影像学研究表明，在孤独的年轻人和中年人之间，功能性脑网络的功能连接模式存在差异。在这里，我们采取有针对性的方法来直接评估与年轻人和老年人孤独感和共情反应相关的功能连接的年龄相关差异。我们发现与孤独和共情反应相关的功能连通性的个体差异随年龄而异。我们讨论了这些关联背后的可能机制，以及它们对成人一生中大脑和社会功能的影响。
Loneliness is associated with differences in resting-state functional connectivity (RSFC) within and between large-scale networks in early- and middle-aged adult cohorts. However, age-related changes in associations between sociality and brain function into late adulthood are not well understood. Here, we examined age differences in the association between two dimensions of sociality—loneliness and empathic responding—and RSFC of the cerebral cortex. Self-report measures of loneliness and empathy were inversely related across the entire sample of younger (mean age = 22.6y, n = 128) and older (mean age = 69.0y, n = 92) adults. Using multivariate analyses of multi-echo fMRI RSFC, we identified distinct functional connectivity patterns for individual and age group differences associated with loneliness and empathic responding. Loneliness in young and empathy in both age groups was related to greater visual network integration with association networks (e.g., default, fronto-parietal control). In contrast, loneliness was positively related to within- and between-network integration of association networks for older adults. These results extend our previous findings in early- and middle-aged cohorts, demonstrating that brain systems associated with loneliness, as well as empathy, differ in older age. Further, the findings suggest that these two aspects of social experience engage different neurocognitive processes across human life-span development. Feelings of loneliness emerge when a person’s desire or need for an interpersonal relationship is unmet. This state of perceived social isolation can influence social-cognitive processes that are critical for connecting with others, such as empathy. Neuroimaging studies have shown diverging functional connectivity patterns among functional brain networks between lonely younger and middle-aged adults. Here, we take a targeted approach to directly assess age-related differences in functional connectivity associated with loneliness and empathic responding in younger and older adults. We find evidence that individual differences in functional connectivity related to loneliness and empathic responding differ with age. We discuss possible mechanisms underlying these associations and their implications for brain and social functioning across the adult life-span.
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DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
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影响因子：
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作者：
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影响因子：
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DOI：
10.1093/geronb/gby084
发表时间：
2020-05-01
影响因子：
6.2
作者：
Bailey, Phoebe E.;Brady, Brooke;Ruffman, Ted
通讯作者：
Ruffman, Ted