Necessity to measure PCBs and organochlorine pesticide concentrations in human umbilical cords for fetal exposure assessment.
Necessity to measure PCBs and organochlorine pesticide concentrations in human umbilical cords for fetal exposure assessment.
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DOI：
10.1289/ehp.7330
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发表时间：
2005-03
影响因子：
10.4
通讯作者：
Mori C
中科院分区：
文献类型：
--
作者：
Fukata H;Omori M;Osada H;Todaka E;Mori C
三种类型的组织样本——脐带 (UC)、脐带血清 (CS) 和母体血清 (MS)——通常用于评估胎儿接触化学品的情况。为了了解母亲和胎儿之间污染的关系，我们测量了三个组织样本的可比较组中的持久性化学物质。此外，我们还分析了母体和胎儿组织中化学物质之间的关联，以了解哪种组织是胎儿暴露评估的最佳样本。在湿基上，化学浓度的顺序为 MS > CS > UC，但某些化学物质（如顺式氯丹和硫丹）除外。在脂质基础上，UC 中的浓度几乎等于或通常高于 MS 中，但 CS 中的浓度通常低于其他中。六氯环己烷和五氯联苯、六氯联苯和七氯联苯显示 UC 与 MS 以及 UC 与 CS 中的浓度之间存在相关性。这些化学物质还显示出第一胎UC中化学物质浓度与母亲年龄之间的高相关系数。当使用聚类分析根据其浓度进行分组时，这些化学物质彼此密切相关。总之，我们坚持认为 UC 是评估持久性化学物质胎儿污染状况的最佳样本。基于CS污染水平的评估有可能导致低估。
Three types of tissue samples—umbilical cord (UC), umbilical cord serum (CS), and maternal serum (MS)—have often been used to assess fetal exposure to chemicals. In order to know the relationship of contamination between mothers and fetuses, we measured persistent chemicals in comparable sets of the three tissue samples. Also, we analyzed the association between the chemicals in maternal and fetal tissues to know which tissue is the best sample for fetal exposure assessment. On a wet basis, the chemical concentrations were of the order MS > CS > UC, except for some chemicals such as cis-chlordane and endosulfan. On a lipid basis, the concentrations in UC were nearly equal or often higher than in MS, but the concentrations in CS were usually lower than in others. Hexachlorocyclohexanes and penta-, hexa-, and heptachlorinated biphenyls showed an association between the concentrations in UC versus MS, and UC versus CS. These chemicals also showed high correlation coefficients between the chemical concentrations in UC of first babies and maternal age. These chemicals were closely related to each other when grouped on the basis of their concentrations using cluster analysis. In conclusion, we insist that UC is the best sample to assess fetal contamination status of persistent chemicals. There is a possibility that the assessment based on the contamination levels in CS result in an underestimation.
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国家儿童对环境对儿童健康和发展的影响的研究。
影响因子：
10.4
作者：
Branum AM;Collman GW;Correa A;Keim SA;Kessel W;Kimmel CA;Klebanoff MA;Longnecker MP;Mendola P;Rigas M;Selevan SG;Scheidt PC;Schoendorf K;Smith-Khuri E;Yeargin-Allsopp M;National Children's Study Interagency Coordinating Committee, Centers for Disease Control and Prevention;National Children's Study Interagency Coordinating Committee, National Institute of Environmental Health Sciences;National Children's Study Interagency Coordinating Committee, National Institute of Child Health and Human Development;National Children's Study Interagency Coordinating Committee, U.S. Environmental Protection Agency
通讯作者：
National Children's Study Interagency Coordinating Committee, U.S. Environmental Protection Agency
影响因子：
9.8
作者：
Walker, JB;Seddon, L;Van Oostdam, J
通讯作者：
Van Oostdam, J
影响因子：
9.8
作者：
Covaci, A;Jorens, P;Schepens, R
通讯作者：
Schepens, R
影响因子：
8.3
作者：
Sarcinelli, PN;Pereira, ACS;Wolff, M
通讯作者：
Wolff, M
影响因子：
6.1
作者：
MOHAMMED, A;EKLUND, A;SLANINA, P
通讯作者：
SLANINA, P