Optical Determination of Cholesterol in Milk with Molecularly Imprinted Polymer-Coated Quantum Dots
Optical Determination of Cholesterol in Milk with Molecularly Imprinted Polymer-Coated Quantum Dots
复制标题
用分子印迹聚合物涂层量子点光学测定牛奶中的胆固醇
DOI：
10.1080/00032719.2016.1255749
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发表时间：
2017-05
影响因子：
2
通讯作者：
Sun Baoguo
中科院分区：
文献类型：
--
作者：
Liu Huilin;Mu Lin;Chen Xiaomo;Wang Jing;Wang Shuo;Sun Baoguo
采用一步法制备了分子印迹荧光聚合物包被CdSe/ZnS量子点。研究了它们作为荧光纳米颗粒直接定量牛奶中胆固醇的应用。量子点被用作产生荧光的核心。分子印迹的聚合物外壳为胆固醇提供了特定的结合位点。该系统在0.5 ~ 150µg mL - 1范围内具有良好的线性关系，低检出限为0.15µg mL - 1, 6个重复的相对标准偏差为4.2%，可接受的重现性。用分子印迹聚合物包被量子点测定强化牛奶中的胆固醇。加样回收率为87.0 ~ 105.2%，并提出了可能的作用机理。荧光分子印迹聚合物包覆量子点具有良好的选择性，提供了一种简单、快速、选择性和有效的分析方法。
ABSTRACT Fluorescent molecularly imprinted polymer-coated CdSe/ZnS quantum dots were prepared in an efficient one-step synthesis. Their application as fluorescent nanoparticles for the direct quantification of cholesterol in milk was characterized. The quantum dots were used as cores to produce fluorescence. The molecularly imprinted polymer shells provided specific binding sites for cholesterol. The system exhibited good linearity for cholesterol from 0.5 to 150 µg mL−1, a low detection limit of 0.15 µg mL−1, and acceptable reproducibility with a relative standard deviation of 4.2% for six replicates. The molecularly imprinted polymer-coated quantum dots were used to determine cholesterol in fortified milk. Recoveries were from 87.0 to 105.2% and a possible mechanism is proposed. The fluorescent molecularly imprinted polymer-coated quantum dots exhibited excellent selectivity and provide a simple, rapid, selective, and effective analytical approach.
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