Longitudinal Changes in Brain Gyrification in Schizophrenia Spectrum Disorders.
Longitudinal Changes in Brain Gyrification in Schizophrenia Spectrum Disorders.
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DOI：
10.3389/fnagi.2021.752575
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发表时间：
2021
影响因子：
4.8
通讯作者：
Suzuki M
中科院分区：
文献类型：
--
作者：
Pham TV;Sasabayashi D;Takahashi T;Takayanagi Y;Kubota M;Furuichi A;Kido M;Noguchi K;Suzuki M
先前的磁共振成像（MRI）研究报告了精神分裂症和分裂型障碍（精神分裂症谱系中的一种原型障碍）的脑旋转增加。这可能反映了早期神经发育的偏差；然而，目前尚不清楚旋转模式是否在精神分裂症谱系的过程中纵向改变。本MRI研究使用FreeSurfer比较了23例首发精神分裂症患者、14例分裂型障碍患者和39例健康对照者的整个皮质局部旋转指数（LGI）的纵向变化（平均扫描间隔2.7年）。两组间纵向LGI变化差异有统计学意义；精神分裂症组表现出LGI的逐渐下降，主要是在额颞叶区域，而分裂型组和对照组的LGI随着时间的推移在几个大脑区域增加。在精神分裂症组中，随着时间的推移，右侧中央前区和中央后区LGI的较大减少与随访期间阴性症状的较小改善相关。随访期间累积用药剂量与分裂型组右侧上顶区纵向LGI升高呈负相关，但对精神分裂症组纵向LGI变化无影响。总的来说，这些结果表明，精神分裂症谱系中的旋回模式既反映了作为易感因素的早期神经发育异常，也反映了精神分裂症早期阶段的活动性脑病理。
Previous magnetic resonance imaging (MRI) studies reported increased brain gyrification in schizophrenia and schizotypal disorder, a prototypic disorder within the schizophrenia spectrum. This may reflect deviations in early neurodevelopment; however, it currently remains unclear whether the gyrification pattern longitudinally changes over the course of the schizophrenia spectrum. The present MRI study using FreeSurfer compared longitudinal changes (mean inter-scan interval of 2.7 years) in the local gyrification index (LGI) in the entire cortex among 23 patients with first-episode schizophrenia, 14 with schizotypal disorder, and 39 healthy controls. Significant differences were observed in longitudinal LGI changes between these groups; the schizophrenia group exhibited a progressive decline in LGI, predominantly in the fronto-temporal regions, whereas LGI increased over time in several brain regions in the schizotypal and control groups. In the schizophrenia group, a greater reduction in LGI over time in the right precentral and post central regions correlated with smaller improvements in negative symptoms during the follow-up period. The cumulative medication dosage during follow-up negatively correlated with a longitudinal LGI increase in the right superior parietal area in the schizotypal group, but did not affect longitudinal LGI changes in the schizophrenia group. Collectively, these results suggest that gyrification patterns in the schizophrenia spectrum reflect both early neurodevelopmental abnormalities as a vulnerability factor and active brain pathology in the early stages of schizophrenia.
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影响因子：
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