Local gyrification index in probands with psychotic disorders and their first-degree relatives.
Local gyrification index in probands with psychotic disorders and their first-degree relatives.
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DOI：
10.1016/j.biopsych.2013.11.018
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发表时间：
2014-09-15
影响因子：
10.6
通讯作者：
Keshavan, Matcheri S.
中科院分区：
文献类型：
--
作者：
Nanda, Pranav;Tandon, Neeraj;Mathew, Ian T.;Giakoumatos, Christoforos I.;Abhishekh, Hulegar A.;Clementz, Brett A.;Pearlson, Godfrey D.;Sweeney, John;Tamminga, Carol A.;Keshavan, Matcheri S.
精神障碍的特征是神经连通性异常。脑回化的改变，即皮层折叠的模式和程度，可能与连接的早期发育有关。过去的旋回研究样本量相对较小，对精神分裂症（SZ）的研究结果好坏参半，对精神病性双相情感障碍（BP）和分裂情感性障碍（SZA）及其相关疾病的研究很少。在这里，我们检查在精神病患者和他们的一级亲属旋转作为一种可能的内表型。由FreeSurfer软件测量的区域局部旋转指数（LGI）值在243名对照者、388名精神病先证者和300名他们的一级亲属之间进行了比较。对于患者，LGI值被分为精神病诊断组，然后分别检测SZ、SZA和BP。还计算了区域LGI值的亲缘性（遗传性）值和与临床测量的相关性。与对照组相比，先显者在三个脑区表现出明显的脑功能减退，II轴A类疾病的亲属在这些相同的区域表现出几乎显著的脑功能减退。这些部位的LGI值具有显著的遗传性，与任何临床测量结果无关。观察到显著的精神障碍似乎以显著的局部脑回功能减退为特征，特别是在扣带皮层。这种异常可能是精神疾病的结构性内表型标记风险，它可能有助于阐明精神疾病的病因学基础。
Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia (SZ), and are scant for psychotic bipolar (BP) and schizoaffective (SZA) disorders and for relatives of these conditions. Here we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype. Regional Local Gyrification Index (LGI) values, as measured by FreeSurfer software, were compared between 243 controls, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values were examined grouped across psychotic diagnoses and then separately for SZ, SZA, and BP. Familiality (heritability) values and correlations with clinical measures were also calculated for regional LGI values. Probands exhibited significant hypogyria compared to controls in three brain regions and relatives with axis II cluster A disorders showed nearly significant hypogyria in these same regions. LGI values in these locations were significantly heritable and uncorrelated with any clinical measure. Observations of significant Psychotic disorders appear to be characterized by significant regionally localized hypogyria, particularly in cingulate cortex. This abnormality may be a structural endophenotype marking risk for psychotic illness and it may help elucidate etiological underpinnings of psychotic disorders.
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影响因子：
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