Cortico-cerebellar interactions during goal-directed behavior.

Cortico-cerebellar interactions during goal-directed behavior.
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DOI:
10.1016/j.conb.2020.08.010
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发表时间:
2020-12
影响因子:
5.7
通讯作者:
Mrsic-Flogel TD
Mrsic-Flogel TD
中科院分区:
医学2区
文献类型:
--
作者:
Li N;Mrsic-Flogel TD

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在目标导向运动之前,在多个相互连接的大脑区域可以观察到预备活动。准备活动反映了离散的活动状态,代表了具体的未来行动。目前尚不清楚这种活动是如何由多区域相互作用介导的。最近的证据表明,小脑通常与精细运动控制有关,有助于新皮层的准备活动。我们回顾了最近的进展,并就目标导向行为中皮质-小脑相互作用的功能提供了观点。我们提出,小脑学习促进新皮层活动状态之间的转换。活动状态之间的转换可以实现灵活和适当定时的行为反应。
Preparatory activity is observed across multiple interconnected brain regions prior to goal-directed movement. Preparatory activity reflects discrete activity states representing specific future actions. It is unclear how this activity is mediated by multi-regional interactions. Recent evidence suggests that the cerebellum, classically associated with fine motor control, contributes to preparatory activity in the neocortex. We review recent advances and offer perspective on the function of cortico-cerebellar interactions during goal-directed behavior. We propose that the cerebellum learns to facilitate transitions between neocortical activity states. Transitions between activity states enable flexible and appropriately timed behavioral responses.
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